Abulí, AnnaCastells, AntoniBujanda, LuisLozano, Juan JoséBessa Caserras, XavierHernández Rodríguez, CristinaAlvarez Urturi, CristinaPellisé, MariaEsteban Jurado, ClaraHijona, ElizabethBuron Pust, AndreaMacià Guilà, Francesc AssísGrau, JaumeGuayta, RafaelCastellví Bel, SergiAndreu García, MontserratPROCOLON research group2016-06-202016-06-202016Abulí A, Castells A, Bujanda L, Lozano JJ, Bessa X, Hernández C. et al. Genetic variants associated with colorectal adenoma susceptibility. PloS One. 2016 Apr 14;11(4):e0153084. DOI: 10.1371/journal.pone.01530841932-6203http://hdl.handle.net/10230/26947BACKGROUND: Common low-penetrance genetic variants have been consistently associated with colorectal cancer risk. AIM: To determine if these genetic variants are associated also with adenoma susceptibility and may improve selection of patients with increased risk for advanced adenomas and/or multiplicity (≥ 3 adenomas). METHODS: We selected 1,326 patients with increased risk for advanced adenomas and/or multiplicity and 1,252 controls with normal colonoscopy from population-based colorectal cancer screening programs. We conducted a case-control association study analyzing 30 colorectal cancer susceptibility variants in order to investigate the contribution of these variants to the development of subsequent advanced neoplasia and/or multiplicity. RESULTS: We found that 14 of the analyzed genetic variants showed a statistically significant association with advanced adenomas and/or multiplicity: the probability of developing these lesions increased with the number of risk alleles reaching a 2.3-fold risk increment in individuals with ≥ 17 risk alleles. CONCLUSIONS: Nearly half of the genetic variants associated with colorectal cancer risk are also related to advanced adenoma and/or multiplicity predisposition. Assessing the number of risk alleles in individuals within colorectal cancer screening programs may help to identify better a subgroup with increased risk for advanced neoplasia and/or multiplicity in the general population.application/pdfspa© 2016 Abulí et al. This is an openaccess article distributed under the terms of the http://creativecommons.org/licenses/by/4.0/, which permitsunrestricted use, distribution, and reproduction in anymedium, provided the original author and source arecredited.Còlon -- Càncer -- Aspectes genèticsinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1371/journal.pone.0153084info:eu-repo/semantics/openAccess