Sinding, Mikkel Holger S.Kuderna, Lukas, 1989-Marquès i Bonet, Tomàs, 1975-Gilbert, M Thomas2023-05-022023-05-022020Sinding MS, Gopalakrishnan S, Ramos-Madrigal J, de Manuel M, Pitulko VV, Kuderna L et al. Arctic-adapted dogs emerged at the Pleistocene-Holocene transition. Science. 2020;368(6498):1495-9. DOI: 10.1126/science.aaz85990036-8075http://hdl.handle.net/10230/56625Although sled dogs are one of the most specialized groups of dogs, their origin and evolution has received much less attention than many other dog groups. We applied a genomic approach to investigate their spatiotemporal emergence by sequencing the genomes of 10 modern Greenland sled dogs, an ~9500-year-old Siberian dog associated with archaeological evidence for sled technology, and an ~33,000-year-old Siberian wolf. We found noteworthy genetic similarity between the ancient dog and modern sled dogs. We detected gene flow from Pleistocene Siberian wolves, but not modern American wolves, to present-day sled dogs. The results indicate that the major ancestry of modern sled dogs traces back to Siberia, where sled dog-specific haplotypes of genes that potentially relate to Arctic adaptation were established by 9500 years ago.application/pdfengThis is the author’s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science on 2020;368(6498). DOI: 10.1126/science.aaz8599info:eu-repo/semantics/articlehttp://dx.doi.org/10.1126/science.aaz8599info:eu-repo/semantics/openAccess