Ruíz Romero, MarinaBlanco, EnriqueParicio, NuriaSerras Rigalt, FlorenciCorominas Guiu, Montserrat2015-11-102015-11-102015Ruiz-Romero M, Blanco E, Paricio N, Serras F, Corominas M. Cabut/dTIEG associates with the transcription factor Yorkie for growth control. EMBO Reports. 2015; 16(3): 362-369. DOI 10.15252/embr.2014391931469-221Xhttp://hdl.handle.net/10230/25037The Drosophila transcription factor Cabut/dTIEG (Cbt) is a growth regulator, whose expression is modulated by different stimuli. Here, we determine Cbt association with chromatin and identify Yorkie (Yki), the transcriptional co-activator of the Hippo (Hpo) pathway as its partner. Cbt and Yki co-localize on common gene promoters, and the expression of target genes varies according to changes in Cbt levels. Down-regulation of Cbt suppresses the overgrowth phenotypes caused by mutations in expanded (ex) and yki overexpression, whereas its up-regulation promotes cell proliferation. Our results imply that Cbt is a novel partner of Yki that is required as a transcriptional co-activator in growth control.application/pdfeng© 2015 The Authors. Published under the terms of the CC BY NC ND 4.0 licenseDrosòfila -- GenèticaRegulació genèticainfo:eu-repo/semantics/articlehttp://dx.doi.org/10.15252/embr.201439193CabutdTIEGGAFGrowthYorkieinfo:eu-repo/semantics/openAccess