Flores de los Heros, África, 1985-Herry, CyrilMaldonado, Rafael, 1961-Berrendero Díaz, Fernando, 1971-2018-03-062018-03-062017Flores A, Herry C, Maldonado R, Berrendero F. Facilitation of Contextual Fear Extinction by Orexin-1 Receptor Antagonism IsAssociated with the Activation of Specific Amygdala Cell Subpopulations. Int J Neuropsychopharmacol. 2017 Aug 1;20(8):654-9. DOI: 10.1093/ijnp/pyx0291461-1457http://hdl.handle.net/10230/34051BACKGROUND: Orexins are hypothalamic neuropeptides recently involved in the regulation of emotional memory. The basolateral amygdala, an area orchestrating fear memory processes, appears to be modulated by orexin transmission during fear extinction. However, the neuronal types within the basolateral amygdala involved in this modulation remain to be elucidated. METHODS: We used retrograde tracing combined with immunofluorescence techniques in mice to identify basolateral amygdala projection neurons and cell subpopulations in this brain region influenced by orexin transmission during contextual fear extinction consolidation. RESULTS: Treatment with the orexin-1 receptor antagonist SB334867 increased the activity of basolateral amygdala neurons projecting to infralimbic medial prefrontal cortex during fear extinction. GABAergic interneurons expressing calbindin, but not parvalbumin, were also activated by orexin-1 receptor antagonism in the basolateral amygdala. CONCLUSIONS: These data identify neuronal circuits and cell populations of the amygdala associated with the facilitation of fear extinction consolidation induced by the orexin-1 receptor antagonist SB334867.application/pdfeng© The Author 2017. Published by Oxford University Press on behalf of CINP. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.comFacilitation of contextual fear extinction by orexin-1 receptor antagonism is associated with the activation of specific amygdala cell subpopulationsinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1093/ijnp/pyx029Fear extinctionOrexinAmygdalaRetrograde labelingCalbindininfo:eu-repo/semantics/openAccess