Molins-Pitarch, CarlaKhao, JonathanBonet, SantiagoJusticia, YolandaAltube, ClementinaGoodstadt, Mike N.Ribot, FrancescLieberman Aiden, ErezNeretti, NicolaMcGill, Gaël G.Marti-Renom, Marc A.2025-10-092025-10-092025Molins-Pitarch C, Khao J, Bonet S, Justicia Y, Altube C, Goodstadt M, et al. Geometric diagrams of genomes: constructing a visual grammar for 3D genomics. Genome Biol. 2025 Jun 26;26(1):181. DOI: 10.1186/s13059-025-03646-y1474-7596http://hdl.handle.net/10230/71440Advances in the field of three-dimensional (3D) genomics have revealed an ever-expanding array of architectural features that were unknown only a few years ago. Just as ribbon diagrams integrate spatial and symbolic representation to communicate the shape of a protein, the representation of genomes in 3D space requires the development and use of new cartographic symbols and visual conventions. Here, we propose a conceptualized grammar that makes it easier to create visual 3D representations of genomes.application/pdfeng© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.Genòmicainfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1186/s13059-025-03646-yinfo:eu-repo/semantics/openAccess