Benaiges Foix, DavidBisbe MariaPedro-Botet, Juan CarlosVargas-Machuca, Aleix deRamón Moros, José ManuelPera Roman, Manuel RamónVillatoro Moreno, MontserratFontane Francia, LaiaJulià, HelenaCliment Biescas, ElisendaCastañer, OlgaFlores-Le-Roux, Juana AntoniaGoday Arno, Alberto2021-10-142021-10-142020Benaiges D, Bisbe M, Pedro-Botet J, de Vargas-Machuca A, Ramon JM, Pera M, et al. Additional metabolic effects of bariatric surgery in patients with a poor mid-term weight loss response: a 5-year follow-up study. J Clin Med. 2020 Oct 1; 9(10): 3193. DOI: 10.3390/jcm91031932077-0383http://hdl.handle.net/10230/48649To ascertain the 5-year metabolic effects of bariatric surgery in poor weight loss (WL) responders and establish associated factors. Methods: Retrospective analysis of a non-randomised prospective cohort of bariatric surgery patients completing a 5-year follow-up. Mid-term poor WL was considered when 5-year excess weight loss was <50%. Results: Forty-three (20.3%) of the 212 included patients were mid-term poor WL responders. They showed an improvement in all metabolic markers at 2 years, except for total cholesterol. This improvement with respect to baseline was maintained at 5 years for plasma glucose, HbA1c, HOMA, HDL and diastolic blood pressure; however, LDL cholesterol, triglycerides and systolic blood pressure were similar to presurgical values. Comorbidity remission rates were comparable to those obtained in the good WL group except for hypercholesterolaemia (45.8% vs. poor WL, p = 0.005). On multivariate analysis, lower baseline HDL cholesterol levels, advanced age and lower preoperative weight loss were independently associated with poor mid-term WL. Conclusions: Although that 1 in 5 patients presented suboptimal WL 5 years after bariatric surgery, other important metabolic benefits were maintained.application/pdfeng© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).info:eu-repo/semantics/articlehttp://dx.doi.org/10.3390/jcm9103193Bariatric surgeryGastric bypassObesitySevere obesitySleeve gastrectomy;Weight lossWeight regaininfo:eu-repo/semantics/openAccess