Solé Vicente, Ricard, 1962-Montañez, RaúlDuran Nebreda, Salvador, 1987-2015-12-092015-12-092015Solé R, Montañez R, Duran-Nebreda S. Synthetic circuit designs for earth terraformation. Biology Direct. 2015;10:37. DOI: 10.1186/s13062-015-0064-71745-6150http://hdl.handle.net/10230/25354Background. Mounting evidence indicates that our planet might experience runaway effects associated to rising temperatures and ecosystem overexploitation, leading to catastrophic shifts on short time scales. Remediation scenarios capable of counterbalancing these effects involve geoengineering, sustainable practices and carbon sequestration, among others. None of these scenarios seems powerful enough to achieve the desired restoration of safe boundaries./nPresentation of the hypothesis. We hypothesize that synthetic organisms with the appropriate engineering design could be used to safely prevent declines in some stressed ecosystems and help improving carbon sequestration. Such schemes would include engineering mutualistic dependencies preventing undesired evolutionary processes. We hypothesize that some particular design principles introduce unescapable constraints to the engineered organisms that act as effective firewalls./nTesting the hypothesis. Testing this designed organisms can be achieved by using controlled bioreactor models, with single and heterogeneous populations, and accurate computational models including different scales (from genetic constructs and metabolic pathways to population dynamics)./nImplications of the hypothesis. Our hypothesis heads towards a future anthropogenic action that should effectively act as Terraforming processes. It also implies a major challenge in the existing biosafety policies, since we suggest release of modified organisms as potentially necessary strategy for success./nReviewers. This article was reviewed by This article was reviewed by Eugene V. Koonin, Tom Ellis (nominated by Purificación Lopez-Garcia) and Eörs Szathmary.application/pdfeng© 2015 Sole et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.Biologia sintèticaCanvis climàticsinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1186/s13062-015-0064-7Synthetic biologyEcological engineeringClimate changeCatastrophic shiftsMutualisminfo:eu-repo/semantics/openAccess