Untersmayr, EvaBax, Heather J.Bergmann, ChristophBianchini, RodolfoCozen, WendyGould, Hannah J.Hartmann, KarinJosephs, Debra H.Levi-Schaffer, FrancescaPenichet, Manuel L.O'Mahony, LiamPoli, AurelieRedegeld, Frank A.Roth-Walter, FranziskaTurner, Michelle C.Vangelista, LucaKaragiannis, Sophia N.Jensen-Jarolim, Erika2022-04-262022-04-262019Untersmayr E, Bax HJ, Bergmann C, Bianchini R, Cozen W, Gould HJ, Hartmann K, Josephs DH, Levi-Schaffer F, Penichet ML, O'Mahony L, Poli A, Redegeld FA, Roth-Walter F, Turner MC, Vangelista L, Karagiannis SN, Jensen-Jarolim E. AllergoOncology: Microbiota in allergy and cancer-A European Academy for Allergy and Clinical Immunology position paper. Allergy. 2019 Jun;74(6):1037-51. DOI: 10.1111/all.137180105-4538http://hdl.handle.net/10230/52890The microbiota can play important roles in the development of human immunity and the establishment of immune homeostasis. Lifestyle factors including diet, hygiene, and exposure to viruses or bacteria, and medical interventions with antibiotics or anti-ulcer medications, regulate phylogenetic variability and the quality of cross talk between innate and adaptive immune cells via mucosal and skin epithelia. More recently, microbiota and their composition have been linked to protective effects for health. Imbalance, however, has been linked to immune-related diseases such as allergy and cancer, characterized by impaired, or exaggerated immune tolerance, respectively. In this AllergoOncology position paper, we focus on the increasing evidence defining the microbiota composition as a key determinant of immunity and immune tolerance, linked to the risk for the development of allergic and malignant diseases. We discuss novel insights into the role of microbiota in disease and patient responses to treatments in cancer and in allergy. These may highlight opportunities to improve patient outcomes with medical interventions supported through a restored microbiome.application/pdfeng© 2019 The Authors. Allergy Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.info:eu-repo/semantics/articlehttp://dx.doi.org/10.1111/all.13718AllergyCancerHygiene hypothesisMicrobiotaOncoimmunologyinfo:eu-repo/semantics/openAccess