Bocharov, Gennady A.Grebennikov, DmitryCebollada Rica, PaulaDomenjó Vila, Eva, 1993-Casella, Valentina, 1991-Meyerhans, Andreas2022-11-142022-11-142022Bocharov G, Grebennikov D, Cebollada Rica P, Domenjo-Vila E, Casella V, Meyerhans A. Functional cure of a chronic virus infection by shifting the virus - host equilibrium state. Front Immunol. 2022 Aug 30;13:904342. DOI: 10.3389/fimmu.2022.9043421664-3224http://hdl.handle.net/10230/54831The clinical handling of chronic virus infections remains a challenge. Here we describe recent progress in the understanding of virus - host interaction dynamics. Based on the systems biology concept of multi-stability and the prediction of multiplicative cooperativity between virus-specific cytotoxic T cells and neutralising antibodies, we argue for the requirements to engage multiple immune system components for functional cure strategies. Our arguments are derived from LCMV model system studies and are translated to HIV-1 infection.application/pdfeng© 2022 Bocharov, Grebennikov, Cebollada Rica, Domenjo-Vila, Casella and Meyerhans. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.info:eu-repo/semantics/articlehttp://dx.doi.org/10.3389/fimmu.2022.904342Chronic virus infectionsHIV (human immunodeficiency virus)LCMV (lymphocytic choriomeningitis virus)Cure strategiesMulti-stabilityShifting equilibrium statesinfo:eu-repo/semantics/openAccess