Defaus, SiraGallo, María, 1989-Abengózar, María ÁngelesRivas, LuisAndreu Martínez, David2017-05-262017-05-262017Defaus S, Gallo M, Abengózar MA, Rivas L, Andreu Martínez D. A Synthetic Strategy for Conjugation of Paromomycin to Cell-Penetrating Tat(48-60) for Delivery and Visualization into Leishmania Parasites. International Journal of Peptides. 2017;2017:4213037. DOI: 10.1155/2017/4213037http://hdl.handle.net/10230/32170A successful approach to deliver paromomycin, a poorly absorbed aminoglycoside antibiotic, to parasite cells is reported, based on selective protection of amino and hydroxyl groups followed by conjugation to a fluorolabeled, PEG-functionalized cell-penetrating Tat(48-60) peptide. The resulting construct is efficiently internalized into Leishmania cells, evidencing the fitness of cell-penetrating peptides as vectors for efficiently transporting low-bioavailability drugs into cells.application/pdfengCopyright © 2017 Sira Defaus et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.info:eu-repo/semantics/articlehttp://dx.doi.org/10.1155/2017/4213037info:eu-repo/semantics/openAccess