Deus, GuillemGómez-Zorrilla, SilviaEcheverría Esnal, DanielSiverio-Parès, AnaGüerri Fernández, RobertoAres, JesúsCampillo Ambrós, NúriaLetang Jiménez de Anta, Emilio ÁngelKnobel Freud, HernandoGrau Cerrato, SantiagoHorcajada Gallego, Juan Pablo2021-06-182021-06-182021Deus G, Gómez-Zorrilla S, Echeverria-Esnal D, Siverio A, Güerri-Fernandez R, Ares J, Campillo N, Letang E, Knobel H, Grau S, Horcajada JP. Osteoarticular cryptococcosis successfully treated with high-dose liposomal amphotericin B followed by oral fluconazole. Infect Drug Resist. 2021;14:719-22. DOI: 10.2147/IDR.S2942991178-6973http://hdl.handle.net/10230/47929Background: Skeletal involvement of Cryptococcus neoformans is infrequent and usually associated with disseminated cryptococcosis or underlying predisposing conditions. We present an atypical case of osteoarticular cryptococcosis in an immunocompetent patient. Case presentation: We herein report a case of bone and soft tissue cryptococcal infection in a 42-year-old male from Pakistan with well-controlled diabetes without other associated immunodeficiencies treated with antifungal therapy without surgical debridement. Furthermore, the patient developed toxidermia due to fluconazole use, so a fluconazole desensitization was performed. Therapeutic management also included the performance of therapeutic drug monitoring of fluconazole plasma concentrations. Conclusion: To our knowledge, this is the first case of osteoarticular cryptococcosis treated with this treatment regimen. This strategy may be of interest to try to reduce hospital stay and associated complications.application/pdfeng© 2021 Deus et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.info:eu-repo/semantics/articlehttp://dx.doi.org/10.2147/IDR.S294299Cryptococcus neoformansFluconazole desensitizationImmunocompetentLiposomal amphotericin BOsteoarticular cryptococcosisinfo:eu-repo/semantics/openAccess