Cannabinoid withdrawal syndrome is reduced in pre-proenkephalin knock-out mice

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• dc.contributor.author Valverde Granados, Olgaca
• dc.contributor.author Maldonado, Rafael, 1961-ca
• dc.contributor.author Valjent, Emmanuelca
• dc.contributor.author Zimmer, Anne M.ca
• dc.contributor.author Zimmer, Andreasca
• dc.date.accessioned 2012-07-05T06:54:19Z
• dc.date.available 2012-07-05T06:54:19Z
• dc.date.issued 2000ca
• dc.description.abstract The functional interactions between the endogenous cannabinoid and opioid systems were evaluated in pre-proenkephalin-deficient mice. Antinociception induced in the tail-immersion test by acute Delta9-tetrahydrocannabinol was reduced in mutant mice, whereas no difference between genotypes was observed in the effects induced on body temperature, locomotion, or ring catalepsy. During a chronic treatment with Delta9-tetrahydrocannabinol, the development of tolerance to the analgesic responses induced by this compound was slower in mice lacking enkephalin. In addition, cannabinoid withdrawal syndrome, precipitated in Delta9-tetrahydrocannabinol-dependent mice by the injection of SR141716A, was significantly attenuated in mutant mice. These results indicate that the endogenous enkephalinergic system is involved in the antinociceptive responses of Delta9-tetrahydrocannabinol and participates in the expression of cannabinoid abstinence.
• dc.description.sponsorship This work was supported by European Commission Grant BIOM ED-2/98–2227 and Fondo de Investigaciones Sanitaria Grant 99/0624 (R.M.), Dr. Esteve S.A. Laboratories, and La Fondation des Treilles, and by a grant from the Land Nordrhein-Westfalen (Innovationsprogramm Forschung) (A.Z.).
• dc.format.mimetype application/pdfca
• dc.identifier.citation Valverde O, Maldonado R, Valjent E, Zimmer AM, Zimmer A. Cannabinoid withdrawal syndrome is reduced in pre-proenkephalin knock-out mice. J Neurosci. 2000;20(24):9284-9. DOI: 10.1523/jneurosci.20-24-09284.2000ca
• dc.identifier.doi http://dx.doi.org/10.1523/jneurosci.20-24-09284.2000
• dc.identifier.issn 0270-6474ca
• dc.identifier.uri http://hdl.handle.net/10230/16670
• dc.language.iso engca
• dc.publisher Society for Neuroscienceca
• dc.relation.ispartof Journal of Neuroscience. 2000;20(24):9284-9
• dc.rights © 2000, Society for Neuroscience. The published version is available at: http://www.jneurosci.org/content/20/24/9284ca
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Cannabinoid
• dc.subject.keyword Opioid
• dc.subject.keyword Mice
• dc.subject.keyword Mutation
• dc.subject.keyword Withdrawal
• dc.subject.keyword Addiction
• dc.subject.keyword Tolerance
• dc.subject.other Cannabinoides -- Efectes fisiològics
• dc.subject.other Cannabinoides -- Receptors
• dc.subject.other Drogoaddicció -- Aspectes moleculars
• dc.title Cannabinoid withdrawal syndrome is reduced in pre-proenkephalin knock-out miceca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/publishedVersion