Comparing high-frequency with monophasic electroporation protocols in an in vivo beating heart model
Mostra el registre complet Registre parcial de l'ítem
- dc.contributor.author Heller, Eyal
- dc.contributor.author Garcia-Sanchez, Tomas
- dc.contributor.author Moshkovits, Yonatan
- dc.contributor.author Rabinovici, Raul
- dc.contributor.author Grynberg, Dvora
- dc.contributor.author Segev, Amit
- dc.contributor.author Asirvatham, Samuel J.
- dc.contributor.author Ivorra Cano, Antoni, 1974-
- dc.contributor.author Maor, Elad
- dc.date.accessioned 2023-02-16T07:06:18Z
- dc.date.available 2023-02-16T07:06:18Z
- dc.date.issued 2021
- dc.description.abstract This study compared monophasic 100-μs pulses with high-frequency electroporation (HF-EP) bursts using an in vivo animal model. Myocardial damage was evaluated by histologic analysis. Compared with 10 monophasic pulses, 20 bursts of HF-EP at 100 and 150 kHz were associated with less damage. However, when the number of HF-EP bursts was increased to 60, myocardial damage was comparable to that of the monophasic group. HF-EP protocols were associated with attenuated collateral muscle contractions. This study shows that HF-EP is feasible and effective and that pulse frequency has a significant effect on extent of ablation.
- dc.description.sponsorship Funded by the Nicholas and Elizabeth Shlezak Super Center for Cardiac Research and Biomedical Engineering at Tel Aviv University; Mayo Clinic–Sheba innovation grant; project (PID2019-110120RBI00/AEI/10.13039/501100011033) from the Ministry of Science, Innovation, and Universities; and the State Research Agency of the Spanish government and by the Beatriu de Pinos program from the Ministry of Business and Knowledge of the Government of Catalonia (grant identifier: 2017 BP 00032). Dr Ivorra gratefully acknowledges financial support by the Catalan Institution for Research and Advanced Studies (ICREA) under the ICREA Academia program.
- dc.format.mimetype application/pdf
- dc.identifier.citation Heller E, Garcia-Sanchez T, Moshkovits Y, Rabinovici R, Grynberg D, Segev A, Asirvatham SJ, Ivorra A, Maor E. Comparing high-frequency with monophasic electroporation protocols in an in vivo beating heart model. JACC Clin Electrophysiol. 2021;7(8):959-64. DOI: 10.1016/j.jacep.2021.05.003
- dc.identifier.doi http://dx.doi.org/10.1016/j.jacep.2021.05.003
- dc.identifier.issn 2405-500X
- dc.identifier.uri http://hdl.handle.net/10230/55794
- dc.language.iso eng
- dc.publisher Elsevier
- dc.relation.ispartof JACC: Clinical Electrophysiology. 2021;7(8):959-64.
- dc.relation.isreferencedby https://ars.els-cdn.com/content/image/1-s2.0-S2405500X21004424-mmc1.mp4
- dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019-110120RBI00
- dc.rights © Elsevier http://dx.doi.org/10.1016/j.jacep.2021.05.003
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.keyword H-FIRE
- dc.subject.keyword electroporation
- dc.subject.keyword muscle contraction
- dc.subject.keyword pulsed field ablation
- dc.title Comparing high-frequency with monophasic electroporation protocols in an in vivo beating heart model
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion