Comparing high-frequency with monophasic electroporation protocols in an in vivo beating heart model

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dc.contributor.authorHeller, Eyal
dc.contributor.authorGarcia-Sanchez, Tomas
dc.contributor.authorMoshkovits, Yonatan
dc.contributor.authorRabinovici, Raul
dc.contributor.authorGrynberg, Dvora
dc.contributor.authorSegev, Amit
dc.contributor.authorAsirvatham, Samuel J.
dc.contributor.authorIvorra Cano, Antoni, 1974-
dc.contributor.authorMaor, Elad
dc.date.accessioned2023-02-16T07:06:18Z
dc.date.available2023-02-16T07:06:18Z
dc.date.issued2021
dc.description.abstractThis study compared monophasic 100-μs pulses with high-frequency electroporation (HF-EP) bursts using an in vivo animal model. Myocardial damage was evaluated by histologic analysis. Compared with 10 monophasic pulses, 20 bursts of HF-EP at 100 and 150 kHz were associated with less damage. However, when the number of HF-EP bursts was increased to 60, myocardial damage was comparable to that of the monophasic group. HF-EP protocols were associated with attenuated collateral muscle contractions. This study shows that HF-EP is feasible and effective and that pulse frequency has a significant effect on extent of ablation.
dc.description.sponsorshipFunded by the Nicholas and Elizabeth Shlezak Super Center for Cardiac Research and Biomedical Engineering at Tel Aviv University; Mayo Clinic–Sheba innovation grant; project (PID2019-110120RBI00/AEI/10.13039/501100011033) from the Ministry of Science, Innovation, and Universities; and the State Research Agency of the Spanish government and by the Beatriu de Pinos program from the Ministry of Business and Knowledge of the Government of Catalonia (grant identifier: 2017 BP 00032). Dr Ivorra gratefully acknowledges financial support by the Catalan Institution for Research and Advanced Studies (ICREA) under the ICREA Academia program.
dc.format.mimetypeapplication/pdf
dc.identifier.citationHeller E, Garcia-Sanchez T, Moshkovits Y, Rabinovici R, Grynberg D, Segev A, Asirvatham SJ, Ivorra A, Maor E. Comparing high-frequency with monophasic electroporation protocols in an in vivo beating heart model. JACC Clin Electrophysiol. 2021;7(8):959-64. DOI: 10.1016/j.jacep.2021.05.003
dc.identifier.doihttp://dx.doi.org/10.1016/j.jacep.2021.05.003
dc.identifier.issn2405-500X
dc.identifier.urihttp://hdl.handle.net/10230/55794
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofJACC: Clinical Electrophysiology. 2021;7(8):959-64.
dc.relation.isreferencedbyhttps://ars.els-cdn.com/content/image/1-s2.0-S2405500X21004424-mmc1.mp4
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/2PE/PID2019-110120RBI00
dc.rights© Elsevier http://dx.doi.org/10.1016/j.jacep.2021.05.003
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.subject.keywordH-FIRE
dc.subject.keywordelectroporation
dc.subject.keywordmuscle contraction
dc.subject.keywordpulsed field ablation
dc.titleComparing high-frequency with monophasic electroporation protocols in an in vivo beating heart model
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion

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