Comparing high-frequency with monophasic electroporation protocols in an in vivo beating heart model

Heller, Eyal; Garcia-Sanchez, Tomas; Moshkovits, Yonatan; Rabinovici, Raul; Grynberg, Dvora; Segev, Amit; Asirvatham, Samuel J.; Ivorra Cano, Antoni, 1974-; Maor, Elad

doi:http://dx.doi.org/10.1016/j.jacep.2021.05.003

Comparing high-frequency with monophasic electroporation protocols in an in vivo beating heart model

Citation

Heller E, Garcia-Sanchez T, Moshkovits Y, Rabinovici R, Grynberg D, Segev A, Asirvatham SJ, Ivorra A, Maor E. Comparing high-frequency with monophasic electroporation protocols in an in vivo beating heart model. JACC Clin Electrophysiol. 2021;7(8):959-64. DOI: 10.1016/j.jacep.2021.05.003

Abstract

This study compared monophasic 100-μs pulses with high-frequency electroporation (HF-EP) bursts using an in vivo animal model. Myocardial damage was evaluated by histologic analysis. Compared with 10 monophasic pulses, 20 bursts of HF-EP at 100 and 150 kHz were associated with less damage. However, when the number of HF-EP bursts was increased to 60, myocardial damage was comparable to that of the monophasic group. HF-EP protocols were associated with attenuated collateral muscle contractions. This study shows that HF-EP is feasible and effective and that pulse frequency has a significant effect on extent of ablation.