Influence of gestational weight gain on the organochlorine pollution content of breast milk

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  • dc.contributor.author Grimalt Obrador, Joan
  • dc.contributor.author Garí de Barbarà, Mercè, 1982-
  • dc.contributor.author Santa Marina, Loreto
  • dc.contributor.author Ibarluzea, Jesús
  • dc.contributor.author Sunyer Deu, Jordi
  • dc.date.accessioned 2022-05-16T06:29:02Z
  • dc.date.available 2022-05-16T06:29:02Z
  • dc.date.issued 2022
  • dc.description.abstract Background: Transplacental transfer and breastfeeding are the main transport routes of organic pollutants into children at the beginning of life. Although pollutant transmission through these mechanisms primarily depends on the maternal pollution burden, its impact may be modulated by physiological effects. Objectives: We have examined whether gestational weight gain (GWG) exerts an influence on the content of lipophilic low volatile pollutants in breast milk. Results: Colostrum from mothers from the INMA cohorts of Sabadell and Gipuzkoa (n = 256 and 119, respectively) with low GWG as defined by the Institute of Medicine (IOM) from the US National Academies of Sciences, Engineering and Medicine had significantly higher concentrations of polychlorobiphenyls (PCBs) and 4,4'-DDE than colostrum in mothers who gained weight within IOM recommendations or in those who exceeded this threshold. Statistically significant differences were also found in the colostrum:maternal serum ratios of these compounds. Women with low GWG retained higher pollutant amounts in colostrum. These observations are consistent with previously described higher concentrations of these pollutants in infant cord blood from mothers with low GWG by IOM standards. They indicate that mobilization of lipophilic organic pollutants by metabolic pregnant changes not only leads to higher fetal transfer but to higher accumulation into the mammary system upon low GWG. Conclusions: The present results show that insufficient GWG, besides increasing in utero exposure, also enhances pollutant transfer to infants during breastfeeding which considerably extends the significance of this physiological change for the pollutant children intake in early life.
  • dc.description.sponsorship The authors are grateful to Silvia Fochs, Anna Sànchez, Maribel López and Nuria Pey, for their assistance in contacting the families and administering the questionnaires, to Corporació Sanitària Parc Taulí for its implication and support, and particularly like to thank all the participants for their generous collaboration. We are also thankful to Marta Fort for the analyses of organohalogen compounds. We acknowledge the collaboration of the municipalities of Zumarraga, Urretxu, Legazpi, Azkoitia, Azpeitia y Beasain. We acknowledge financial support from the European Union, project EDCMET (H2020-HEALTH/0490–825762). This study was also funded by grants from the Instituto de Salud Carlos III (PI06/0867, Red INMA G03/176 and FIS-PI18/01142), the Department of Health of the Basque Government (2005111093) and the Provincial Government of Gipuzkoa (DFG06/002). M. G. acknowledges the support from the Joachim Herz Foundation through the Add-on Fellowship for Interdisciplinary Science.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Grimalt JO, Garí M, Santa-Marina L, Ibarluzea J, Sunyer J. Influence of gestational weight gain on the organochlorine pollution content of breast milk. Environ Res. 2022 Jun;209:112783. DOI: 10.1016/j.envres.2022.112783
  • dc.identifier.doi http://dx.doi.org/10.1016/j.envres.2022.112783
  • dc.identifier.issn 0013-9351
  • dc.identifier.uri http://hdl.handle.net/10230/53083
  • dc.language.iso eng
  • dc.publisher Elsevier
  • dc.relation.ispartof Environ Res. 2022 Jun;209:112783
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/825762
  • dc.rights © 2022 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by- nc-nd/4.0/).
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
  • dc.subject.keyword Breastfeeding
  • dc.subject.keyword Gestational weight gain
  • dc.subject.keyword Maternal transfer of organic pollutants
  • dc.subject.keyword Organohalogen compounds
  • dc.title Influence of gestational weight gain on the organochlorine pollution content of breast milk
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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