Transient receptor potential genes, smoking, occupational exposures and cough in adults

Smit, Lidwien AM; Kogevinas, Manolis; Antó i Boqué, Josep Maria; Bouzigon, Emmanuelle; González Ruiz, Juan Ramón; Moual, Nicole Le; Kromhout, Hans; Carsin, Anne-Elie; Pin, Isabelle; Jarvis, Deborah; Vermeulen, Roel; Janson, Christer; Heinrich, Joachim; Gut, Ivo Glynne; Lathrop, Mark; Valverde, M. A. (Miguel Ángel), 1963-; Demenais, Florence; Kauffmann, Francine

Transient receptor potential genes, smoking, occupational exposures and cough in adults

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dc.contributor.author Smit, Lidwien AMca
dc.contributor.author Kogevinas, Manolisca
dc.contributor.author Antó i Boqué, Josep Mariaca
dc.contributor.author Bouzigon, Emmanuelleca
dc.contributor.author González Ruiz, Juan Ramónca
dc.contributor.author Moual, Nicole Leca
dc.contributor.author Kromhout, Hansca
dc.contributor.author Carsin, Anne-Elieca
dc.contributor.author Pin, Isabelleca
dc.contributor.author Jarvis, Deborahca
dc.contributor.author Vermeulen, Roelca
dc.contributor.author Janson, Christerca
dc.contributor.author Heinrich, Joachimca
dc.contributor.author Gut, Ivo Glynneca
dc.contributor.author Lathrop, Markca
dc.contributor.author Valverde, M. A. (Miguel Ángel), 1963-ca
dc.contributor.author Demenais, Florenceca
dc.contributor.author Kauffmann, Francineca
dc.date.accessioned 2015-03-26T10:52:29Z
dc.date.available 2015-03-26T10:52:29Z
dc.date.issued 2012ca
dc.description.abstract Background: Transient receptor potential (TRP) vanilloid and ankyrin cation channels are activated by various noxious chemicals and may play an important role in the pathogenesis of cough. The aim was to study the influence of single nucleotide polymorphisms (SNPs) in TRP genes and irritant exposures on cough. Methods: Nocturnal, usual, and chronic cough, smoking, and job history were obtained by questionnaire in 844 asthmatic and 2046 non-asthmatic adults from the Epidemiological study on the Genetics and Environment of Asthma (EGEA) and the European Community Respiratory Health Survey (ECRHS). Occupational exposures to vapors, gases, dusts, and/or fumes were assessed by a job-exposure matrix. Fifty-eight tagging SNPs in TRPV1, TRPV4, and TRPA1 were tested under an additive model. Results: Statistically significant associations of 6 TRPV1 SNPs with cough symptoms were found in non-asthmatics after correction for multiple comparisons. Results were consistent across the eight countries examined. Haplotype-based association analysis confirmed the single SNP analyses for nocturnal cough (7-SNP haplotype: p-global = 4.8 × 10-6) and usual cough (9-SNP haplotype: p-global = 4.5 × 10-6). Cough symptoms were associated with exposure to irritants such as cigarette smoke and occupational exposures (p < 0.05). Four polymorphisms in TRPV1 further increased the risk of cough symptoms from irritant exposures in asthmatics and non-asthmatics (interaction p < 0.05). Conclusions: TRPV1 SNPs were associated with cough among subjects without asthma from two independent studies in eight European countries. TRPV1 SNPs may enhance susceptibility to cough in current smokers and in subjects with a history of workplace exposures.en
dc.description.sponsorship The EGEA study was funded by INSERM, grants from the French Agency for Environmental and Occupational Health Safety (grant AFSSET-APR-SE-2004), the French National Agency for Research (grants ANR 05-SEST-020-02/05-9-97, ANR 06-CEBS and ANR 10-PRSP) and Merck Sharp & Dohme (MSD)en
dc.format.mimetype application/pdfca
dc.identifier.citation Smit LAM, Kogevinas M, Antó JM, Bouzigon E, González J, Le Moual N et al. Transient receptor potential genes, smoking, occupational exposures and cough in adults. Respiratory Research. 2012; 13: 26. DOI 10.1186/1465-9921-13-26ca
dc.identifier.doi http://dx.doi.org/10.1186/1465-9921-13-26
dc.identifier.issn 1465-9921ca
dc.identifier.uri http://hdl.handle.net/10230/23292
dc.language.iso engca
dc.publisher BioMed Centralca
dc.relation.ispartof Respiratory Research. 2012;13:26
dc.rights © 2012 Smit et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.ca
dc.rights.accessRights info:eu-repo/semantics/openAccessca
dc.rights.uri http://creativecommons.org/licenses/by/2.0
dc.subject.keyword Asthmaen
dc.subject.keyword Gene-environment interactionen
dc.subject.keyword Irritant exposureen
dc.subject.keyword Smokingen
dc.subject.keyword TRP channelen
dc.subject.other Asma -- Epidemiologiaca
dc.subject.other Epidemiologia genèticaca
dc.subject.other Tabac -- Efectes fisiològicsca
dc.title Transient receptor potential genes, smoking, occupational exposures and cough in adultsen
dc.type info:eu-repo/semantics/articleca
dc.type.version info:eu-repo/semantics/publishedVersionca

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