Electrochemical prevention of needle-tract seeding

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• dc.contributor.author Ivorra Cano, Antoni, 1974-ca
• dc.date.accessioned 2016-04-28T11:28:03Z
• dc.date.available 2016-04-28T11:28:03Z
• dc.date.issued 2011ca
• dc.description.abstract Needle-tract seeding refers to the implantation of tumor cells by contamination when instruments, such as biopsy needles, are employed to examine, excise or ablate a tumor. The incidence of this iatrogenic phenomenon is low but it entails serious consequences. Here, as a new method for preventing neoplasm seeding, it is proposed to cause electrochemical reactions at the instrument surface so that a toxic microenvironment is formed. In particular, the instrument shaft would act as the cathode and the tissues would act as the electrolyte in an electrolysis cell. By employing numerical models and experimental observations reported by researchers on Electrochemical Treatment of tumors, it is numerically showed that a sufficiently toxic environment of supraphysiological pH can be created in a few seconds without excessive heating. Then, by employing an ex vivo model consisting of meat pieces, validity of the conclusions provided by the numerical model concerning pH evolution is confirmed. Furthermore, a simplified in vitro model based on bacteria, instead of tumor cells, is implemented for showing the plausibility of the method. Depending on the geometry of the instrument, suitable current densities will probably range from about 5 mA/cm2 to 200 mA/cm2 and the duration of DC current delivery will range from a few seconds to a few minutes.en
• dc.description.sponsorship AI’s research is currently supported by a Ramón y Cajal fellowship from the Spanish Ministry for Science and Innovation.en
• dc.format.mimetype application/pdfca
• dc.identifier.citation Ivorra A. Electrochemical prevention of needle-tract seeding. Ann Biomed Eng. 2011;39(7):2080-89. DOI:10.1007/s10439-011-0295-4ca
• dc.identifier.doi http://dx.doi.org/10.1007/s10439-011-0295-4
• dc.identifier.issn 0090-6964ca
• dc.identifier.uri http://hdl.handle.net/10230/26213
• dc.language.iso engca
• dc.publisher Springerca
• dc.relation.ispartof Annals of biomedical engineering. 2011;39(7):2080-89.
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/TEC2014-52383-C3-2-R
• dc.rights © Springer The final publication is available at Springer via/nhttp://dx.doi.org/10.1007/s10439-011-0295-4ca
• dc.rights.accessRights info:eu-repo/semantics/openAccessca
• dc.subject.keyword Neoplasm seedingen
• dc.subject.keyword Needle-tract seedingen
• dc.subject.keyword Tumor cell disseminationen
• dc.subject.keyword Electrochemical treatmenten
• dc.title Electrochemical prevention of needle-tract seedingca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/acceptedVersionca