Nitrogen dioxide exposure, attentional function, and working memory in children from 4 to 8 years: Periods of susceptibility from pregnancy to childhood

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  • dc.contributor.author Crooijmans, Kellie L. H. A.
  • dc.contributor.author Iñiguez, Carmen
  • dc.contributor.author Withworth, Kristina W.
  • dc.contributor.author Estarlich, Marisa
  • dc.contributor.author Lertxundi, Aitana
  • dc.contributor.author Fernández-Somoano, Ana
  • dc.contributor.author Tardón, Adonina
  • dc.contributor.author Ibarluzea, Jesús
  • dc.contributor.author Sunyer Deu, Jordi
  • dc.contributor.author Guxens Junyent, Mònica
  • dc.contributor.author Binter, Anne-Claire
  • dc.date.accessioned 2024-07-08T13:05:07Z
  • dc.date.available 2024-07-08T13:05:07Z
  • dc.date.issued 2024
  • dc.description.abstract Background: Air pollution exposure during pregnancy and childhood has been linked to executive function impairment in children, however, very few studies have assessed these two exposure periods jointly to identify susceptible periods of exposure. We sought to identify potential periods of susceptibility of nitrogen dioxide (NO2) exposure from conception to childhood on attentional function and working memory in school-aged children. Methods: Within the Spanish INMA Project, we estimated residential daily NO2 exposures during pregnancy and up to 6 years of childhood using land use regression models (n = 1,703). We assessed attentional function at 4-6 years and 6-8 years, using the Conners Kiddie Continuous Performance Test and the Attention Network Test, respectively, and working memory at 6-8 years, using the N-back task. We used distributed lag non-linear models to assess the periods of susceptibility of each outcome, adjusting for potential confounders and correcting for multiple testing. We also stratified all models by sex. Results: Higher exposure to NO2 between 1.3 and 1.6 years of age was associated with higher hit reaction time standard error (HRT-SE) (0.14 ms (95 % CI 0.05; 0.22) per 10 μg/m3 increase in NO2) and between 1.5 and 2.2 years of age with more omission errors (1.02 (95 % CI 1.01; 1.03) of the attentional function test at 4-6 years. Higher exposure to NO2 between 0.3 and 2.2 years was associated with higher HRT-SE (10.61 ms (95 % CI 3.46; 17.75) at 6-8 years only in boys. We found no associations between exposure to NO2 and working memory at 6-8 years. Conclusion: Our findings suggest that NO2 exposure during the first two years of life is associated with poorer attentional function in children from 4 to 8 years of age, especially in boys. These findings highlight the importance of exploring long-term effects of traffic-related air pollution exposure in older age groups.
  • dc.description.sponsorship This study was funded by grants from UE (FP7-ENV-2011 cod 282,957 and HEALTH.2010.2.4.5–1), Spain: the Instituto de Salud Carlos III (Red INMA G03/176, CB06/02/0041, PI041436; PI081151; FIS-FEDER: PI03/1615, PI04/1509, PI04/1112, PI04/1931, PI042018, PI05/1079, PI05/1052, PI06/0867, PI06/1213, PI07/0314, PI09/00090, PI09/02311, PI09/02647, PI11/01007, PI11/02591, PI11/02038, PI12/00610, PI13/02187, PI13/02429, PI13/1944, PI13/2032, PI14/00891, PI14/01687, PI16/1288, and PI17/00663, PI18/00909; Miguel Servet-FEDER CP11/00178, CP15/00025, CPII16/00051, and MSII16/00051), the National Institutes of Health/National Institute of Environmental Health Sciences (NIH/NIEHS) (R01ES028842), Generalitat Valenciana: FISABIO (UGP 15–230, UGP-15–244, and UGP-15–249), Alicia Koplowitz Foundation 2017, Generalitat de Catalunya-CIRIT 1999SGR 00241, Fundació La marató de TV3 (090430), CIBERESP, Generalitat de Catalunya-AGAUR 2009 SGR 501, EU Commission (261357), Fundación Cajastur and Universidad de Oviedo, Department of Health of the Basque Government (2005111093, 2009111069, 2,013,111,089 and 2015111065), the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu, Legazpi, Azkoitia y Azpeitia y Beasain). This study received funding from the European Union’s Horizon 2020 research and innovation program under grant agreements No 824989 (EUCAN-Connect), No 733206 (LifeCycle project) and No 874583 (ATHLETE project). This publication reflects only the authors’ view and the European Commission is not responsible for any use that may be made of the information it contains. M.G. was funded by a Miguel Servet fellowship (CPII18/ 00018) awarded by the Spanish Institute of Health Carlos III. ISGlobal acknowledges support from the grant CEX2018-000806-S funded by MCIN/AEI/10.13039/501100011033, and support from the Generalitat de Catalunya through the CERCA Program.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Crooijmans KLHA, Iñiguez C, Withworth KW, Estarlich M, Lertxundi A, Fernández-Somoano A, et al. Nitrogen dioxide exposure, attentional function, and working memory in children from 4 to 8 years: Periods of susceptibility from pregnancy to childhood. Environ Int. 2024 Apr;186:108604. DOI: 10.1016/j.envint.2024.108604
  • dc.identifier.doi http://dx.doi.org/10.1016/j.envint.2024.108604
  • dc.identifier.issn 0160-4120
  • dc.identifier.uri http://hdl.handle.net/10230/60693
  • dc.language.iso eng
  • dc.publisher Elsevier
  • dc.relation.ispartof Environ Int. 2024 Apr;186:108604
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/282957
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/261357
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/824989
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/733206
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/874583
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/CEX2018-000806-S
  • dc.rights © 2024 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.other Aire--Contaminació
  • dc.subject.other Infants
  • dc.title Nitrogen dioxide exposure, attentional function, and working memory in children from 4 to 8 years: Periods of susceptibility from pregnancy to childhood
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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