Effects of residential greenness during pregnancy on childhood asthma, rhinitis, eczema, and their comorbidity: findings from the French mother-child cohort Pélagie

Patlán-Hernández, Alan R.; Monfort, Christine; Audureau, Etienne; Cirach, Marta; Epaud, Ralph; de Hoogh, Kees; Lanone, Sophie; Montazeri, Parisa, 1988-; Vienneau, Danielle; Warembourg, Charline; Chevrier, Cécile; Savouré, Marine; Jacquemin Leonard, Bénédicte

Effects of residential greenness during pregnancy on childhood asthma, rhinitis, eczema, and their comorbidity: findings from the French mother-child cohort Pélagie

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dc.contributor.author Patlán-Hernández, Alan R.
dc.contributor.author Monfort, Christine
dc.contributor.author Audureau, Etienne
dc.contributor.author Cirach, Marta
dc.contributor.author Epaud, Ralph
dc.contributor.author de Hoogh, Kees
dc.contributor.author Lanone, Sophie
dc.contributor.author Montazeri, Parisa, 1988-
dc.contributor.author Vienneau, Danielle
dc.contributor.author Warembourg, Charline
dc.contributor.author Chevrier, Cécile
dc.contributor.author Savouré, Marine
dc.contributor.author Jacquemin Leonard, Bénédicte
dc.date.accessioned 2025-06-26T06:29:16Z
dc.date.available 2025-06-26T06:29:16Z
dc.date.issued 2025
dc.description.abstract Maternal exposure to residential greenness during pregnancy may influence childhood respiratory and allergic diseases development. Yet, evidence is limited and results are not consistent, furthermore most studies focus on urban areas. In a predominantly rural population, we aimed to assess the effect of maternal residential greenness during pregnancy on childhood asthma, rhinitis, eczema, and their comorbidity. We analyzed data from 1325 to 1119 participants in the 6- and 12-year follow-ups of the Pélagie mother-child cohort in Brittany, France. Ever asthma, rhinitis, and eczema were defined using validated questionnaires, and a multimorbidity phenotype was constructed. Greenness was assessed using the Normalized Difference Vegetation Index (NDVI) within a 300m buffer around the residential address. Adjusted logistic regressions per 0.1-unit increase in NDVI were performed, further stratifying by urban and rural areas. At inclusion, 78 % of mothers were non-smokers, 64 % lived in rural areas, and their average age was 30 ± 4 years; 50 % of children were boys. Median NDVI differed significantly between urban (0.45) and rural (0.57) areas (p=<0.0001). Asthma, rhinitis, and eczema prevalence were respectively around 10 %, 20 %, and 20 % at both follow-ups. Overall, the NDVI within 300m did not show significant associations at either follow-up, across the whole study population, except for eczema (0.87 (0.76-1.00), p=0.05), and the single-disease category of the multimorbidity phenotype (0.87, (0.76-0.99), p=0.03) at 6 years, where it showed protective associations. Our findings highlight the need for further research, particularly in rural populations, to clarify the relationship between prenatal residential greenness and childhood health outcomes.
dc.description.sponsorship This work is part of the REMEDIA project funded by the European Union's Horizon 2020 research and innovation programme under grant agreement No 874753.
dc.format.mimetype application/pdf
dc.identifier.citation Patlán-Hernández AR, Monfort C, Audureau E, Cirach M, Epaud R, de Hoogh K, et al. Effects of residential greenness during pregnancy on childhood asthma, rhinitis, eczema, and their comorbidity: findings from the French mother-child cohort Pélagie. Environ Res. 2025 Aug 15;279(Pt 1):121730. DOI: 10.1016/j.envres.2025.121730
dc.identifier.doi http://dx.doi.org/10.1016/j.envres.2025.121730
dc.identifier.issn 0013-9351
dc.identifier.uri http://hdl.handle.net/10230/70761
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Environ Res. 2025 Aug 15;279(Pt 1):121730
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/874753
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
dc.subject.keyword Asthma
dc.subject.keyword Children
dc.subject.keyword Degree of urbanization
dc.subject.keyword Eczema
dc.subject.keyword Greenness
dc.subject.keyword Rhinitis
dc.title Effects of residential greenness during pregnancy on childhood asthma, rhinitis, eczema, and their comorbidity: findings from the French mother-child cohort Pélagie
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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