Discovery of key whole-brain transitions and dynamics during human wakefulness and non-REM sleep

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  • dc.contributor.author Stevner, Angus B. A.
  • dc.contributor.author Vidaurre, Diego
  • dc.contributor.author Cabral, Joana
  • dc.contributor.author Rapuano, Kristina M.
  • dc.contributor.author Nielsen, Søren Føns Vind
  • dc.contributor.author Tagliazucchi, Enzo
  • dc.contributor.author Laufs, Helmut
  • dc.contributor.author Vuust, Peter
  • dc.contributor.author Deco, Gustavo
  • dc.contributor.author Woolrich, Mark W.
  • dc.contributor.author van Someren, Eus
  • dc.contributor.author Kringelbach, Morten L.
  • dc.date.accessioned 2020-02-18T15:24:47Z
  • dc.date.available 2020-02-18T15:24:47Z
  • dc.date.issued 2019
  • dc.description.abstract The modern understanding of sleep is based on the classification of sleep into stages defined by their electroencephalography (EEG) signatures, but the underlying brain dynamics remain unclear. Here we aimed to move significantly beyond the current state-of-the-art description of sleep, and in particular to characterise the spatiotemporal complexity of whole-brain networks and state transitions during sleep. In order to obtain the most unbiased estimate of how whole-brain network states evolve through the human sleep cycle, we used a Markovian data-driven analysis of continuous neuroimaging data from 57 healthy participants falling asleep during simultaneous functional magnetic resonance imaging (fMRI) and EEG. This Hidden Markov Model (HMM) facilitated discovery of the dynamic choreography between different whole-brain networks across the wake-non-REM sleep cycle. Notably, our results reveal key trajectories to switch within and between EEG-based sleep stages, while highlighting the heterogeneities of stage N1 sleep and wakefulness before and after sleep.
  • dc.description.sponsorship G.D. was supported by the Spanish Research Project PSI2016-75688-P (AEI/FEDER) and by the European Union’s Horizon 2020 research and innovation programme under Grant agreement no. 720270 (HBP SGA1). M.L.K. was supported by the ERC Consolidator Grant CAREGIVING (615539) and the Center for Music in the Brain, funded by the Danish National Research Foundation Grant DNRF117. J.C. was supported under the project NORTE-01-0145-FEDER-000023.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Stevner ABA, Vidaurre D, Cabral J, Rapuano KM, Nielsen SFV, Tagliazucchi E, Laufs H, Vuust P, Deco G, Woolrich MX, Van Someren E, Kringelbach ML. Discovery of key whole-brain transitions and dynamics during human wakefulness and non-REM sleep. Nat Commun. 2019 Dec 1;10(1):1035. DOI: 10.1038/s41467-019-08934-3
  • dc.identifier.doi http://dx.doi.org/10.1038/s41467-019-08934-3
  • dc.identifier.issn 2041-1723
  • dc.identifier.uri http://hdl.handle.net/10230/43644
  • dc.language.iso eng
  • dc.publisher Nature Research
  • dc.relation.ispartof Nature Communications. 2019 Dec 1;10(1):1035
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/720270
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/PSI2016-75688-P
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/ERC/615539
  • dc.rights This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Electroencephalography - EEG
  • dc.subject.keyword Functional magnetic resonance imaging
  • dc.subject.keyword Non-REM sleep
  • dc.subject.keyword Sleep
  • dc.title Discovery of key whole-brain transitions and dynamics during human wakefulness and non-REM sleep
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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