Nonequilibrium brain dynamics as a signature of consciousness
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- dc.contributor.author Sanz Perl, Yonatan
- dc.contributor.author Bocaccio, Hernán
- dc.contributor.author Pallavicini, Carla
- dc.contributor.author Pérez-Ipiña, Ignacio
- dc.contributor.author Laureys, Steven
- dc.contributor.author Laufs, Helmut
- dc.contributor.author Kringelbach, Morten L.
- dc.contributor.author Deco, Gustavo
- dc.contributor.author Tagliazucchi, Enzo
- dc.date.accessioned 2023-03-08T07:25:33Z
- dc.date.available 2023-03-08T07:25:33Z
- dc.date.issued 2021
- dc.description.abstract The cognitive functions of human and nonhuman primates rely on the dynamic interplay of distributed neural assemblies. As such, it seems unlikely that cognition can be supported by macroscopic brain dynamics at the proximity of equilibrium. We confirmed this hypothesis by investigating electrocorticography data from nonhuman primates undergoing different states of unconsciousness (sleep, and anesthesia with propofol, ketamine, and ketamine plus medetomidine), and functional magnetic resonance imaging data from humans, both during deep sleep and under propofol anesthesia. Systematically, all states of reduced consciousness unfolded at higher proximity to equilibrium compared to conscious wakefulness, as demonstrated by the computation of entropy production and the curl of probability flux in phase space. Our results establish nonequilibrium macroscopic brain dynamics as a robust signature of consciousness, opening the way for the characterization of cognition and awareness using tools from statistical mechanics.
- dc.format.mimetype application/pdf
- dc.identifier.citation Sanz Perl Y, Bocaccio H, Pallavicini C, Pérez-Ipiña I, Laureys S, Laufs H, Kringelbach M, Deco G, Tagliazucchi E. Nonequilibrium brain dynamics as a signature of consciousness. Phys Rev E. 2021;104(1):014411. DOI: 10.1103/PhysRevE.104.014411
- dc.identifier.doi http://dx.doi.org/10.1103/PhysRevE.104.014411
- dc.identifier.issn 2470-0045
- dc.identifier.uri http://hdl.handle.net/10230/56107
- dc.language.iso eng
- dc.publisher American Physical Society
- dc.relation.ispartof Physical Review E. 2021;104(1):014411.
- dc.relation.isreferencedby https://journals.aps.org/pre/supplemental/10.1103/PhysRevE.104.014411/supp_info.pdf
- dc.rights © American Physical Society. Published article available at https://doi.org/10.1103/PhysRevE.104.014411
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.keyword Biological complexity
- dc.subject.keyword Neuroscience
- dc.subject.keyword Brain
- dc.subject.keyword Cortical networks
- dc.subject.keyword Mammals
- dc.subject.keyword Nervous system
- dc.subject.keyword Electroencephalography
- dc.subject.keyword Functional magnetic resonance imaging
- dc.subject.keyword Phase space dynamics
- dc.subject.keyword Theories of collective dynamics & active matter
- dc.title Nonequilibrium brain dynamics as a signature of consciousness
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion