A stratified treatment algorithm in psychiatry: a program on stratified pharmacogenomics in severe mental illness (Psych-STRATA): concept, objectives and methodologies of a multidisciplinary project funded by Horizon Europe

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  • dc.contributor.author Baune, Bernhard T.
  • dc.contributor.author Dierssen, Mara
  • dc.contributor.author Ziller, Jacques
  • dc.date.accessioned 2025-02-24T07:20:13Z
  • dc.date.available 2025-02-24T07:20:13Z
  • dc.date.issued 2024
  • dc.description Data de publicació electrònica: 27-12-2024
  • dc.description.abstract Schizophrenia (SCZ), bipolar (BD) and major depression disorder (MDD) are severe psychiatric disorders that are challenging to treat, often leading to treatment resistance (TR). It is crucial to develop effective methods to identify and treat patients at risk of TR at an early stage in a personalized manner, considering their biological basis, their clinical and psychosocial characteristics. Effective translation of theoretical knowledge into clinical practice is essential for achieving this goal. The Psych-STRATA consortium addresses this research gap through a seven-step approach. First, transdiagnostic biosignatures of SCZ, BD and MDD are identified by GWAS and multi-modal omics signatures associated with treatment outcome and TR (steps 1 and 2). In a next step (step 3), a randomized controlled intervention study is conducted to test the efficacy and safety of an early intensified pharmacological treatment. Following this RCT, a combined clinical and omics-based algorithm will be developed to estimate the risk for TR. This algorithm-based tool will be designed for early detection and management of TR (step 4). This algorithm will then be implemented into a framework of shared treatment decision-making with a novel mental health board (step 5). The final focus of the project is based on patient empowerment, dissemination and education (step 6) as well as the development of a software for fast, effective and individualized treatment decisions (step 7). The project has the potential to change the current trial and error treatment approach towards an evidence-based individualized treatment setting that takes TR risk into account at an early stage.
  • dc.description.sponsorship The Psych-STRATA project has received funding from the European Union’s Horizon Europe research and innovation programme under grant agreement No 101057454. BTB received funding from the German Federal Ministry of Health (BMG) [2521FSB004_PROMPT, ERAPERMED2020] and La Marato TV3: SLD044/20/000001 (Convocatoria ERAPERMED2020). MD received funding from PROMPT and La Marato TV3: SLD044/20/000001 (Convocatoria ERAPERMED2020) + Amb el suport del Departament de Salut, Fundació La Marató de TV3, 202212-30. AHY independent research is funded by the National Institute for Health and Care Research (NIHR) Maudsley Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London. The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. For the purposes of open access, the author has applied a Creative Commons Attribution (CC BY) licence to any Accepted Author Manuscript version arising from this submission. M-CP was supported with funding from the Investissement d’Avenir (ANR-10-AIHU-06).
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Baune BT, Fromme SE, Aberg M, Adli M, Afantitis A, Akkouh I, et al. A stratified treatment algorithm in psychiatry: a program on stratified pharmacogenomics in severe mental illness (Psych-STRATA): concept, objectives and methodologies of a multidisciplinary project funded by Horizon Europe. Eur Arch Psychiatry Clin Neurosci. 2024 Dec 27. DOI: 10.1007/s00406-024-01944-3
  • dc.identifier.doi http://dx.doi.org/10.1007/s00406-024-01944-3
  • dc.identifier.issn 0940-1334
  • dc.identifier.uri http://hdl.handle.net/10230/69685
  • dc.language.iso eng
  • dc.publisher Springer
  • dc.relation.ispartof Eur Arch Psychiatry Clin Neurosci. 2024 Dec 27
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/HE/101057454
  • dc.rights © The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Depression schizophrenia
  • dc.subject.keyword Early detection
  • dc.subject.keyword Early treatment
  • dc.subject.keyword Precision psychiatry
  • dc.subject.keyword Treatment resistance
  • dc.title A stratified treatment algorithm in psychiatry: a program on stratified pharmacogenomics in severe mental illness (Psych-STRATA): concept, objectives and methodologies of a multidisciplinary project funded by Horizon Europe
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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