Whole heart detailed and quantitative anatomy, myofibre structure and vasculature from X-ray phase-contrast synchrotron radiation-based micro computed tomography

Gonzalez-Tendero, Anna; Zhang, Chong; Balicevic, Vedrana; Cárdenes, Rubén; Loncaric, Sven; Butakoff, Constantine; Paun, Bruno; Bonnin, Anne; Garcia Canadilla, Patricia; Muñoz-Moreno, Emma; Gratacós Solsona, Eduard; Crispi Brillas, Fàtima; Bijnens, Bart

doi:http://dx.doi.org/10.1093/ehjci/jew314

Whole heart detailed and quantitative anatomy, myofibre structure and vasculature from X-ray phase-contrast synchrotron radiation-based micro computed tomography

Citació

Gonzalez-Tendero A, Zhang C, Balicevic V, Cárdenes R, Loncaric S, Butakoff C, Paun B, Bonnin A, Garcia-Cañadilla P, Muñoz-Moreno E, Gratacós E, Crispi F, Bijnens B. Whole heart detailed and quantitative anatomy, myofibre structure and vasculature from X-ray phase-contrast synchrotron radiation-based micro computed tomography. Eur Heart J Cardiovasc Imaging. 2017 Jul 1;18(7):732-41. DOI: 10.1093/ehjci/jew314

Resum

While individual cardiac myocytes only have a limited ability to shorten, the heart efficiently pumps a large volume-fraction thanks to a cell organization in a complex 3D fibre structure. Subclinical subtle cardiac structural remodelling is often present before symptoms arise. Understanding and early detection of these subtle changes is crucial for diagnosis and prevention. Additionally, personalized computational modelling requires knowledge on the multi-scale structure of the whole heart and vessels.