Human pluripotent stem cells to model islet defects in diabetes

Balboa, Diego; Iworima, Diepiriye G.; Kieffer, Timothy J.

doi:http://dx.doi.org/10.3389/fendo.2021.642152

Human pluripotent stem cells to model islet defects in diabetes

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Balboa D, Iworima DG, Kieffer TJ. Human pluripotent stem cells to model islet defects in diabetes. Front Endocrinol (Lausanne). 2021 Mar 22;12:642152. DOI: 10.3389/fendo.2021.642152

Abstract

Diabetes mellitus is characterized by elevated levels of blood glucose and is ultimately caused by insufficient insulin production from pancreatic beta cells. Different research models have been utilized to unravel the molecular mechanisms leading to the onset of diabetes. The generation of pancreatic endocrine cells from human pluripotent stem cells constitutes an approach to study genetic defects leading to impaired beta cell development and function. Here, we review the recent progress in generating and characterizing functional stem cell-derived beta cells. We summarize the diabetes disease modeling possibilities that stem cells offer and the challenges that lie ahead to further improve these models.