Snail1-driven plasticity of epithelial and mesenchymal cells sustains cancer malignancy.
Mostra el registre complet Registre parcial de l'ítem
- dc.contributor.author Baulida i Estadella, Josep, 1965-ca
- dc.contributor.author García de Herreros, Antonioca
- dc.date.accessioned 2015-10-14T11:20:30Z
- dc.date.available 2016-08-31T02:00:04Z
- dc.date.issued 2015
- dc.description.abstract The transcription factor Snail1 induces epithelial-to-mesenchymal transition (EMT) in tumor epithelial cells, a process associated with the emergence of stemness, invasion and cancer malignancy. Here, we review recent reports indicating that Snail1 also regulates mesenchymal plasticity and paracrine signaling and propose that Snail1 orchestrates the generation of cancer stem cells (CSCs) and cancer-associated fibroblasts (CAFs). Our view supports the current models for tumorigenesis that consider stemness and tumor microenvironment as retroactive actors for metastasis formation, revealing Snail1 as a regulator of these metastatic forces. This view offers new perspectives for understanding and targeting metastasis.ca
- dc.format.mimetype application/pdfca
- dc.identifier.citation Baulida J, García de Herreros A. Snail1-driven plasticity of epithelial and mesenchymal cells sustains cancer malignancy. Biochim Biophys Acta. 2015 Aug;1856(1):55-61. DOI: 10.1016/j.bbcan.2015.05.005ca
- dc.identifier.doi http://dx.doi.org/10.1016/j.bbcan.2015.05.005
- dc.identifier.issn 0006-3002
- dc.identifier.uri http://hdl.handle.net/10230/24846
- dc.language.iso engca
- dc.publisher Elsevierca
- dc.relation.ispartof Biochimica et Biophysica Acta. 2015 Aug;1856(1):55-61
- dc.rights © 2015 Elsevier B.V. All rights reservedca
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.keyword Metastasis
- dc.subject.keyword EMT Epithelial to mesenchymal transition
- dc.subject.keyword Snail1
- dc.subject.keyword CAF Cancer associated fibroblasts
- dc.subject.keyword CSC Cancer stem cell
- dc.subject.keyword Tumor microenvironment
- dc.subject.keyword Mechanical signalling
- dc.subject.keyword TGF-beta
- dc.title Snail1-driven plasticity of epithelial and mesenchymal cells sustains cancer malignancy.ca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/acceptedVersionca