Bone material strength is associated with areal BMD but not with prevalent fractures in older women.

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• dc.contributor.author Rudäng, R.ca
• dc.contributor.author Zoulaki, M.ca
• dc.contributor.author Sundh, D.ca
• dc.contributor.author Brisby, Helenaca
• dc.contributor.author Díez Pérez, Adolfoca
• dc.contributor.author Johansson, L.ca
• dc.contributor.author Mellström, D.ca
• dc.contributor.author Darelid, Annaca
• dc.contributor.author Lorentzon, Mattiasca
• dc.date.accessioned 2016-03-16T12:11:18Z
• dc.date.available 2016-03-16T12:11:18Z
• dc.date.issued 2016
• dc.description.abstract Reference point indentation is a novel method to assess bone material strength index (BMSi) in vivo. We found that BMSi at the mid-tibia was weakly associated with spine and hip areal bone mineral density but not with prevalent fracture in a population-based cohort of 211 older women. INTRODUCTION: Reference point indentation is a novel method to assess BMSi in vivo. Lower BMSi has been observed in patients with prior fracture than in controls, but no association between BMSi and areal bone mineral density (aBMD) has been found. Population-based association studies and prospective studies with BMSi and fractures are lacking. We hypothesized that BMSi would be associated with prevalent fractures in older Swedish women. The aim was to investigate the associations between BMSi, aBMD, and prevalent fracture in older women. METHODS: Two hundred eleven women, mean age 78.3 ± 1.1 years, were included in this cross-sectional, population-based study. BMSi was assessed using the OsteoProbe device at the mid-tibia. Areal BMD of the hip, spine, and non-dominant radius was measured using dual-energy X-ray absorptiometry (DXA). Fracture history was retrieved using questionnaires, and vertebral fractures were identified using vertebral fracture assessment (VFA) by DXA. RESULTS: One hundred ninety-eight previous fractures in 109 subjects were reported. A total of 106 women had a vertebral fracture, of which 58 women had moderate or severe fractures. An inverse correlation between BMSi and weight (r = -0.14, p = 0.04) was seen, and BMSi differed according to operator (ANOVA p < 0.01). Adjusting for weight and operator in a linear regression model, we found that BMSi was positively associated with aBMD of the total hip (β = 0.14, p = 0.04), non-dominant radius (β = 0.17, p = 0.02), and lumbar spine (L1-L4) (β = 0.14, p < 0.05). Using logistic regression, we could not find any association in crude or adjusted BMSi (for age, weight, height, walking speed, calcium intake, smoking, bisphosphonate and glucocorticoid use, and operator) with prevalent fractures. CONCLUSION: We conclude that BMSi is associated with aBMD but not with prevalent fracture in a population-based cohort of 211 older women.ca
• dc.description.sponsorship This study was funded by the Swedish Research Council (VR), the Lundberg Foundation, Gothenburg Society of Medicine (GLS), the ALF/LUA grant from the Sahlgrenska University Hospital, and Gustaf V:s och Drottning Victorias Frimurarstiftelse.
• dc.format.mimetype application/pdfca
• dc.identifier.citation Rudäng R, Zoulakis M, Sundh D, Brisby H, Diez-Perez A, Johansson L. et al. Bone material strength is associated with areal BMD but not with prevalent fractures in older women. Osteoporos Int. 2016 Apr;27(4):1585-92. doi: 10.1007/s00198-015-3419-0.ca
• dc.identifier.doi http://dx.doi.org/10.1007/s00198-015-3419-0
• dc.identifier.issn 0937-941X
• dc.identifier.uri http://hdl.handle.net/10230/25995
• dc.language.iso engca
• dc.publisher Springer Verlagca
• dc.relation.ispartof Osteoporosis International. 2016 Apr;27(4):1585-92
• dc.rights This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.ca
• dc.rights.accessRights info:eu-repo/semantics/openAccessca
• dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/ca
• dc.subject.other Ossos -- Fisiologiaca
• dc.subject.other Fracturesca
• dc.title Bone material strength is associated with areal BMD but not with prevalent fractures in older women.ca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/publishedVersionca