Cancer mortality in an international cohort of reinforced plastics workers exposed to styrene: a reanalysis
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- dc.contributor.author Loomis, Dana
- dc.contributor.author Guha, Neela
- dc.contributor.author Kogevinas, Manolis
- dc.contributor.author Fontana, Vincenzo
- dc.contributor.author Gennaro, Valerio
- dc.contributor.author Kolstad, Henrik A.
- dc.contributor.author McElvenny, Damien Martin
- dc.contributor.author Sallmén, Markku
- dc.contributor.author Saracci, Rodolfo
- dc.date.accessioned 2022-05-31T07:00:25Z
- dc.date.available 2022-05-31T07:00:25Z
- dc.date.issued 2019
- dc.description.abstract Objective: To investigate the carcinogenicity of styrene by reanalysing data from a previous international cohort study of workers in the reinforced plastics industry. Methods: Mortality from cancers of prior interest was analysed with more detailed consideration of exposure-response relations and an updated classification of leukaemias and lymphomas in data from a previous international cohort study of 37 021 reinforced plastics workers exposed to airborne styrene. Results: Increased mortality from non-Hodgkin's lymphoma (NHL) was associated with the mean level of exposure to styrene in air (relative risk (RR) 2.31, 95% CI 1.29 to 4.12 per 100 ppm), but not with cumulative styrene exposure. Similar associations with mean exposure were observed for the oesophagus (RR 2.44, 95% CI 1.11 to 5.36 per 100 ppm) and pancreas (RR 1.89, 95% CI 1.17 to 3.09). Oesophageal cancer mortality was also associated with cumulative styrene exposure lagged 20 years (RR 1.16, 95% CI 1.03 to 1.31). No other cancer, including lung cancer, was associated with any indicator of styrene exposure. Conclusion: This reanalysis does not substantially change the conclusions of the original study with respect to NHL or lung cancer but new evidence concerning cancers of the oesophagus and pancreas merits further investigation.
- dc.format.mimetype application/pdf
- dc.identifier.citation Loomis D, Guha N, Kogevinas M, Fontana V, Gennaro V, Kolstad HA, McElvenny DM, Sallmén M, Saracci R. Cancer mortality in an international cohort of reinforced plastics workers exposed to styrene: a reanalysis. Occup Environ Med. 2019 Mar;76(3):157-62. DOI: 10.1136/oemed-2018-105131
- dc.identifier.doi http://dx.doi.org/10.1136/oemed-2018-105131
- dc.identifier.issn 1351-0711
- dc.identifier.uri http://hdl.handle.net/10230/53320
- dc.language.iso eng
- dc.publisher BMJ Publishing Group
- dc.relation.ispartof Occup Environ Med. 2019 Mar;76(3):157-62
- dc.rights © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
- dc.subject.keyword Cancer
- dc.subject.keyword Disease
- dc.subject.keyword Disease type
- dc.subject.keyword Epidemiology
- dc.subject.keyword Organ system
- dc.title Cancer mortality in an international cohort of reinforced plastics workers exposed to styrene: a reanalysis
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion