A structural perspective of compensatory evolution

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• dc.contributor.author Ivankov, Dmitry N.
• dc.contributor.author Finkelstein, Alexei V.
• dc.contributor.author Kondrashov, Fyodor A., 1979-
• dc.date.accessioned 2024-01-29T07:20:01Z
• dc.date.available 2024-01-29T07:20:01Z
• dc.date.issued 2014
• dc.description.abstract The study of molecular evolution is important because it reveals how protein functions emerge and evolve. Recently, several types of studies indicated that substitutions in molecular evolution occur in a compensatory manner, whereby the occurrence of a substitution depends on the amino acid residues at other sites. However, a molecular or structural basis behind the compensation often remains obscure. Here, we review studies on the interface of structural biology and molecular evolution that revealed novel aspects of compensatory evolution. In many cases structural studies benefit from evolutionary data while structural data often add a functional dimension to the study of molecular evolution.
• dc.description.sponsorship The work has been supported by a grant of the HHMI International Early Career Scientist Program (55007424), the Spanish Ministry of Economy and Competitiveness (EUI-EURYIP-2011-4320) as part of the EMBO YIP program, two grants from the Spanish Ministry of Economy and Competitiveness, ‘Centro de Excelencia Severo Ochoa 2013–2017 (Sev-2012-0208)’ and (BFU2012-31329), the European Union and the European Research Council grant (335980_EinME), RFBR (13-04-00253a), MCB RAS (01201358029) and MES RK Grants.
• dc.format.mimetype application/pdf
• dc.identifier.citation Ivankov DN, Finkelstein AV, Kondrashov FA. A structural perspective of compensatory evolution. Current Opinion in Structural Biology. 2014 Jun;26:104-12. DOI: 10.1016/j.sbi.2014.05.004
• dc.identifier.doi http://dx.doi.org/10.1016/j.sbi.2014.05.004
• dc.identifier.issn 0959-440
• dc.identifier.uri http://hdl.handle.net/10230/58840
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Current Opinion in Structural Biology. 2014 Jun;26:104-12
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/335980
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SEV-2012-0208
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2012-31329
• dc.rights © 2014 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/
• dc.subject.other Proteïnes
• dc.subject.other Molècules
• dc.subject.other Aminoàcids
• dc.title A structural perspective of compensatory evolution
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion