Characterization of myocardial deformation in patients with different etiologies of left ventricular hypertrophy by using strain distribution from Magnetic Resonance Imaging

Piella Fenoy, Gemma; Craene, Mathieu de; Bijnens, Bart; Tobón Gómez, Catalina, 1981-; Huguet, Marina; Avegliano, Gustavo P.; Frangi Caregnato, Alejandro

doi:http://dx.doi.org/10.1016/S1885-5857(10)70253-X

Characterization of myocardial deformation in patients with different etiologies of left ventricular hypertrophy by using strain distribution from Magnetic Resonance Imaging

Citation

Piella G, De Craene M, Bijnens B, Tobon-Gómez C, Huguet M, Avegliano G, Frangi AF. Characterization of myocardial deformation in patients with different etiologies of left ventricular hypertrophy by using strain distribution from Magnetic Resonance Imaging. Rev Esp Cardiol. 2010; 63(11): 1281-1291. DOI 10.1016/S0300-8932(10)70298-0

Abstract

Introduction and objectives. It has been suggested that in hypertrophic cardiomyopathy (HCM) the regional fibre disarray results in segments of none or severely reduced deformation, distributed non-uniformly within the left ventricle (LV). This is in contrast with other types of hypertrophies such as athlete’s heart or hypertensive left ventricular hypertrophy (HT-LVH) which may have abnormal cardiac deformation but never as reduced as showing absence of deformation in certain segments. Hence, we propose to use the distribution of the strain values to study deformation in HCM./nMethods. Using tagged magnetic resonance imaging, we reconstructed the LV systolic deformation from 12/ncontrols, 10 athletes, 12 patients with HCM and 10 patients with HT-LVH. Deformation was quantified using a fast nonrigid registration algorithm and measuring radial and circumferential peak systolic strain values from 16 LV segments./nResults. HCM patients showed significantly lower average strain values when compared to other groups./nHowever, while the deformation in healthy subjects and HT-LVH was concentrated around the mean value, in HCM there was a coexistence of segments with normal contraction and segments with none or significantly reduced deformation, resulting in a larger heterogeneity of the strain values. Some non-deforming segments were also found in the absence of fibrosis or hypertrophy./nConclusions. Strain distribution characterizes specific patterns of myocardial deformation in patients with/ndifferent etiologies of LVH. HCM patients had significantly lower average strain as well as/n2larger strain heterogeneity (compared to controls, athletes and HT-LVH), and they presented non-deforming regions.

Other authors

Universitat Pompeu Fabra

Alternative title

Caracterización de la deformación miocárdica en pacientes con hipertrofia ventricular izquierda de diferente etiología/nmediante el uso de distribuciones de strain obtenidas de imágenes de resonancia magnética