Hindbrain rhombomere centers harbor an heterogenous population of dividing progenitors
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- dc.contributor.author Hernández Martin, Ariadna
- dc.date.accessioned 2023-07-26T10:02:57Z
- dc.date.available 2023-07-26T10:02:57Z
- dc.date.issued 2023
- dc.description Treball de fi de grau en Biologia Humanaca
- dc.description Co-directores: Cristina Pujades Corbi, Lydvina Meister
- dc.description Tutor acadèmic: José Francisco Aramburu Beltran (Universitat Pompeu Fabra)
- dc.description.abstract During embryonic development, tissue growth and morphogenesis are interconnected processes and their regulation is essential to correctly develop an organism. This regulation involves the controlled production of different cell types and the precise allocation of stem cell capacities at the right time. The embryonic zebrafish hindbrain is a notable example of how the spatial and temporal acquisition of cell diversity is linked to tissue growth, as neurogenesis depends on the position of progenitor cells along the anteroposterior axis. However, the exact coordination mechanisms behind this process are not fully understood. Through a combination of cell lineage and in vivo imaging, we have discovered certain characteristics of the cell population located in the hindbrain rhombomeric centers. By performing clonal analysis, we have investigated the proliferative capacity of this region, providing new insights into the behavior of this cell population. This work shows the spatiotemporal molecular profile of rhombomeric center. Moreover, our findings suggest that rhombomere centers harbor a heterogeneous progenitor population where proliferative capacities get restricted around 48hpf and this territory gets arrested in G1 cell phase of the cell cycle. In conclusion, centers of rhombomeres present characteristics comparable to long lasting progenitors.ca
- dc.format.mimetype application/pdf
- dc.identifier.uri http://hdl.handle.net/10230/57677
- dc.language.iso engca
- dc.rights Reconeixement-NoComercial-SenseObraDerivada 4.0 Internacional (CC BY-NC-ND 4.0)
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ca
- dc.subject.other Neurobiologia del desenvolupament
- dc.subject.other Romboencèfal
- dc.title Hindbrain rhombomere centers harbor an heterogenous population of dividing progenitorsca
- dc.type info:eu-repo/semantics/bachelorThesisca