Comparative genomics reveals the hybrid origin of a macaque group
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- dc.contributor.author Zhang, Bao-Lin
- dc.contributor.author Marquès i Bonet, Tomàs, 1975-
- dc.contributor.author Wu, Dong-Dong
- dc.date.accessioned 2023-07-14T06:38:55Z
- dc.date.available 2023-07-14T06:38:55Z
- dc.date.issued 2023
- dc.description.abstract Although species can arise through hybridization, compelling evidence for hybrid speciation has been reported only rarely in animals. Here, we present phylogenomic analyses on genomes from 12 macaque species and show that the fascicularis group originated from an ancient hybridization between the sinica and silenus groups ~3.45 to 3.56 million years ago. The X chromosomes and low-recombination regions exhibited equal contributions from each parental lineage, suggesting that they were less affected by subsequent backcrossing and hence could have played an important role in maintaining hybrid integrity. We identified many reproduction-associated genes that could have contributed to the development of the mixed sexual phenotypes characteristic of the fascicularis group. The phylogeny within the silenus group was also resolved, and functional experimentation confirmed that all extant Western silenus species are susceptible to HIV-1 infection. Our study provides novel insights into macaque evolution and reveals a hybrid speciation event that has occurred only very rarely in primates.
- dc.description.sponsorship This work was funded by the National Key Research and Development Program of China (nos. 2021YFF0702700 and 2022YFF0710901), the National Natural Science Foundation of China (no. 31822048 to D.-D.W. and no. 32270500 to B.-L.Z.), Yunnan Applied Basic Research Projects (no. 2019FI010 to D.-D.W.), CAS Light of West China Program (xbzg-zdsys-202213) and the Animal Branch of the Germplasm Bank of Wild Species of Chinese Academy of Science (the Large Research Infrastructure Funding). This work was also partially supported by a Villum Investigator Grant to G.Z. (no. 25900) and the National Natural Science Foundation of China to Y.-T.Z. (U1802284). T.M.-B. was supported by funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (no. 864203), BFU2017-86471-P (MINECO/FEDER, UE), and Howard Hughes International Early Career.
- dc.format.mimetype application/pdf
- dc.identifier.citation Zhang BL, Chen W, Wang Z, Pang W, Luo MT, Wang S, Shao Y, et al. Comparative genomics reveals the hybrid origin of a macaque group. Sci Adv. 2023 Jun 2;9(22):eadd3580. DOI: 10.1126/sciadv.add3580
- dc.identifier.doi http://dx.doi.org/10.1126/sciadv.add3580
- dc.identifier.issn 2375-2548
- dc.identifier.uri http://hdl.handle.net/10230/57570
- dc.language.iso eng
- dc.publisher American Association for the Advancement of Science (AAAS)
- dc.relation.ispartof Sci Adv. 2023 Jun 2;9(22):eadd3580
- dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/864203
- dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/BFU2017-86471-P
- dc.rights © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
- dc.title Comparative genomics reveals the hybrid origin of a macaque group
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion