Copycat innate lymphoid cells dampen gut inflammation.

Magri, Giuliana, 1978-; Cerutti, Andrea, 1965-

doi:http://dx.doi.org/10.1038/cr.2015.79

Copycat innate lymphoid cells dampen gut inflammation.

Citació

Magri G, Cerutti A. Copycat innate lymphoid cells dampen gut inflammation. Cell Res. 2015 Sep;25(9):991-2. doi: 10.1038/cr.2015.79.

Resum

The mechanisms whereby the gut mucosa tolerates trillions of commensal bacteria without developing inflammation remain poorly understood. A recent Science article reveals that gut innate lymphoid cells constrain inflammatory T cell responses to commensal bacteria by adopting a strategy usually deployed by thymic epithelial cells to negatively select self-reactive T cells.