Conservative route to genome compaction in a miniature annelid

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  • dc.contributor.author Irimia Martínez, Manuel
  • dc.contributor.author Vellutini, Bruno C.
  • dc.contributor.author Marlétaz, Ferdinand
  • dc.contributor.author Cetrangolo, Viviana
  • dc.contributor.author Cvetesic, Nevena
  • dc.contributor.author Thiel, Daniel
  • dc.contributor.author Henriet, Simon
  • dc.contributor.author Grau Bové, Xavier
  • dc.contributor.author Carrillo-Baltodano, Allan M.
  • dc.contributor.author Gu, Wenjia
  • dc.contributor.author Kerbl, Alexandra
  • dc.contributor.author Marquez, Yamile
  • dc.contributor.author Bekkouche, Nicolas
  • dc.contributor.author Chourrout, Daniel
  • dc.contributor.author Gómez Skarmeta, José Luis
  • dc.contributor.author Lenhard, Boris
  • dc.contributor.author Worsaae, Katrine
  • dc.contributor.author Hejnol, Andreas
  • dc.date.accessioned 2020-12-18T07:23:57Z
  • dc.date.available 2020-12-18T07:23:57Z
  • dc.date.issued 2020
  • dc.description.abstract The causes and consequences of genome reduction in animals are unclear because our understanding of this process mostly relies on lineages with often exceptionally high rates of evolution. Here, we decode the compact 73.8-megabase genome of Dimorphilus gyrociliatus, a meiobenthic segmented worm. The D. gyrociliatus genome retains traits classically associated with larger and slower-evolving genomes, such as an ordered, intact Hox cluster, a generally conserved developmental toolkit and traces of ancestral bilaterian linkage. Unlike some other animals with small genomes, the analysis of the D. gyrociliatus epigenome revealed canonical features of genome regulation, excluding the presence of operons and trans-splicing. Instead, the gene-dense D. gyrociliatus genome presents a divergent Myc pathway, a key physiological regulator of growth, proliferation and genome stability in animals. Altogether, our results uncover a conservative route to genome compaction in annelids, reminiscent of that observed in the vertebrate Takifugu rubripes.
  • dc.description.sponsorship This study was supported by Sars Centre core budget and the European Research Council (ERC) grant agreement no. 648861 to A.H. J.M.M.-D. was additionally supported by the ERC grant agreement no. 801669, and B.C.V. by an EMBO Long-Term Fellowship (ALTF 74-2018). J.L.G.-S. received funding from the ERC (grant agreement no. 740041) and the Spanish Ministerio de Economía y Competitividad (grant no. BFU2016-74961-P) and the institutional grant Unidad de Excelencia María de Maeztu (MDM-2016-0687)
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Martín-Durán JM, Vellutini BC, Marlétaz F, Cetrangolo V, Cvetesic N, Thiel D. Conservative route to genome compaction in a miniature annelid. Nat Ecol Evol. 2020 Nov 16;5:231-42. DOI: 10.1038/s41559-020-01327-6
  • dc.identifier.doi http://dx.doi.org/10.1038/s41559-020-01327-6
  • dc.identifier.issn 2397-334X
  • dc.identifier.uri http://hdl.handle.net/10230/46083
  • dc.language.iso eng
  • dc.publisher Nature Research
  • dc.relation.ispartof Nature Ecology & Evolution. 2020 Nov 16;5:231-42
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/648861
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/801669
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/740041
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2016-74961-P
  • dc.rights © José M. Martín-Durán et al. 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.other Genomes
  • dc.subject.other Animals
  • dc.title Conservative route to genome compaction in a miniature annelid
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion