Pre and postnatal exposure to mercury and respiratory health in preschool children from the Spanish INMA Birth Cohort Study

Carrasco, Paula; Estarlich, Marisa; Iñiguez, Carmen; Ferrero, Amparo; Murcia, Mario; Esplugues, Ana; Vioque, Jesus; Santa Marina, Loreto; Zabaleta, Carlos; Iriarte, Gorka; Fernández-Somoano, Ana; Tardón, Adonina; Vrijheid, Martine; Sunyer Deu, Jordi; Ballester Díez, Ferran; Llop, Sabrina

Pre and postnatal exposure to mercury and respiratory health in preschool children from the Spanish INMA Birth Cohort Study

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dc.contributor.author Carrasco, Paula
dc.contributor.author Estarlich, Marisa
dc.contributor.author Iñiguez, Carmen
dc.contributor.author Ferrero, Amparo
dc.contributor.author Murcia, Mario
dc.contributor.author Esplugues, Ana
dc.contributor.author Vioque, Jesus
dc.contributor.author Santa Marina, Loreto
dc.contributor.author Zabaleta, Carlos
dc.contributor.author Iriarte, Gorka
dc.contributor.author Fernández-Somoano, Ana
dc.contributor.author Tardón, Adonina
dc.contributor.author Vrijheid, Martine
dc.contributor.author Sunyer Deu, Jordi
dc.contributor.author Ballester Díez, Ferran
dc.contributor.author Llop, Sabrina
dc.date.accessioned 2022-06-02T06:02:34Z
dc.date.available 2022-06-02T06:02:34Z
dc.date.issued 2021
dc.description.abstract Effects of mercury on maturing immune system have been reported, however the association with respiratory and allergy problems during infancy remains unclear. The aim of this study is to evaluate the association between pre and postnatal mercury exposure and respiratory and allergy problems among preschool children and to examine the role of potential modifying factors. Study subjects were children participant in Spanish Childhood and Environment Project (INMA, 2003-2008). We measured total mercury levels in cord blood (n = 1868) and hair at 4 years of age (n = 1347). Respiratory outcomes (wheezing, severe wheezing, chestiness, persistent cough, eczema and otitis) were obtained by questionnaires administered to parents. Associations were investigated by logistic regression adjusted for socio-demographic and lifestyle-related variables in each cohort and subsequent meta-analysis. We tested effect modification by factors related to individual susceptibility, diet and co-exposure with other pollutants. The geometric mean of cord blood and hair total mercury was 8.20 μg/L and 0.97 μg/g, respectively. No statistically significant association between pre or postnatal mercury exposure and respiratory and allergy outcomes was found. Notwithstanding, lower maternal intake of fruits and vegetables increased the risk of some respiratory outcomes due to the prenatal exposure to mercury (pint < 0.05). Moreover, an inverse association between prenatal mercury exposure and some respiratory outcomes was observed among children with higher maternal exposure to organocholorine compounds or smoking (pint < 0.05). Also, sex and postnatal smoking exposure modulated mercury postnatal effects on persistent cough (pint < 0.05). In conclusion, no association between pre and postnatal mercury exposure and respiratory and allergy problems among the whole population at study was found. However, diet and other toxicants could modulate this relation, especially during prenatal period. More research on this topic is warranted due to the limited evidence.
dc.description.sponsorship This study was funded by Grants from UE (FP7-ENV-2011 cod 282957 and HEALTH.2010.2.4.5-1), Spain: ISCIII (Red INMA G03/176, CB06/02/0041; FIS-FEDER: PI03/1615, PI04/1509, PI04/1112, PI04/1931, PI04/2018, PI04/1436, PI05/1079, PI05/1052, PI06/1213, PI06/0867, PI07/0314, PI08/1151, PI09/00090, PI09/02647, PI09/2311, PI11/01007, PI11/02591, PI11/02038, PI13/2429, PI13/02187, PI13/1944, PI13/2032, PI14/00891, PI14/01687, PI16/1288, PI17/00663, PI18/01142, PI18/0909, PI19/1338; Miguel Servet-FEDER: CP15/0025; Miguel Servet-FSE: MS15/0025, MS20/0006), Generalitat Valenciana: FISABIO (UGP 15-230, UGP-15-244, and UGP-15-249), BEST/2020/059, AICO/2020/285 and GV/2020/058, Alicia Koplowitz Foundation 2017, Generalitat de Catalunya-CIRIT 1999SGR 00241, Fundació la Marató de TV3 (090430), CIBERESP, Obra Social Cajastur/Fundación Liberbank, Universidad de Oviedo, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065), and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu, Legazpi, Azkoitia y Azpeitia y Beasain).
dc.format.mimetype application/pdf
dc.identifier.citation Carrasco P, Estarlich M, Iñiguez C, Ferrero A, Murcia M, Esplugues A, Vioque J, Marina LS, Zabaleta C, Iriarte G, Fernández-Somoano A, Tardon A, Vrijheid M, Sunyer J, Ballester F, Llop S. Pre and postnatal exposure to mercury and respiratory health in preschool children from the Spanish INMA Birth Cohort Study. Sci Total Environ. 2021 Aug 15;782:146654. DOI: 10.1016/j.scitotenv.2021.146654
dc.identifier.doi http://dx.doi.org/10.1016/j.scitotenv.2021.146654
dc.identifier.issn 0048-9697
dc.identifier.uri http://hdl.handle.net/10230/53356
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Sci Total Environ. 2021 Aug 15;782:146654
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/282957
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.keyword Children
dc.subject.keyword Eczema
dc.subject.keyword Mercury
dc.subject.keyword Prenatal
dc.subject.keyword Respiratory
dc.title Pre and postnatal exposure to mercury and respiratory health in preschool children from the Spanish INMA Birth Cohort Study
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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