Epidemiology of human papillomavirus-related oropharyngeal cancer in a classically low-burden region of southern Europe

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• dc.contributor.author Mena, Marisa
• dc.contributor.author Lloveras Rubio, Belen
• dc.contributor.author Guix Arnau, Marta, 1974-
• dc.contributor.author Hijano Esque, Rafael
• dc.contributor.author Alemany, Laia
• dc.date.accessioned 2022-02-17T07:52:23Z
• dc.date.available 2022-02-17T07:52:23Z
• dc.date.issued 2020
• dc.description.abstract The incidence of human papillomavirus (HPV)-related oropharyngeal cancer is increasing in some regions. Nevertheless, the epidemiology of this disease has not been extensively investigated in southern Europe. We conducted a retrospective cohort study of patients diagnosed with primary oropharyngeal cancer from 1991 to 2016. Cancer tissues underwent histopathological evaluation, DNA quality control, HPV-DNA detection and p16INK4a immunohistochemistry. Data were collected from medical records. Factors associated with HPV positivity and time trends were evaluated with multivariable Bayesian models. The adjusted prevalence of HPV-related cases in 864 patients with a valid HPV-DNA result was 9.7%, with HPV-DNA/p16INK4a double positivity being considered. HPV-related oropharyngeal cancer was likely to occur in non-smokers and non-drinkers, to be located in the tonsil or diagnosed at advanced stages. Time-trend analysis showed an increasing risk of HPV-related oropharyngeal cancer in the most recent periods (5-year period increase of 30%). This increase was highest and with a clear increasing trend only in the most recent years (2012-2016). The prevalence of HPV-related oropharyngeal cancer started to sharply increase in the most recent years in our setting, as occurred two decades ago in areas where most oropharyngeal cancer cases are currently HPV-related. Our results provide a comprehensive assessment of the epidemiological landscape of HPV-related oropharyngeal cancer in a region of southern Europe.
• dc.format.mimetype application/pdf
• dc.identifier.citation Mena M, Frias-Gomez J, Taberna M, Quirós B, Marquez S, Clavero O, et al. Epidemiology of human papillomavirus-related oropharyngeal cancer in a classically low-burden region of southern Europe. Sci Rep. 2020 Aug 6; 10(1): 13219. DOI: 10.1038/s41598-020-70118-7
• dc.identifier.doi http://dx.doi.org/10.1038/s41598-020-70118-7
• dc.identifier.issn 2045-2322
• dc.identifier.uri http://hdl.handle.net/10230/52512
• dc.language.iso eng
• dc.publisher Nature Research
• dc.rights Copyright © The Author(s) 2020. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.other Papil·lomavirus
• dc.subject.other Faringe--Càncer--Europa
• dc.subject.other Epidemiologia
• dc.title Epidemiology of human papillomavirus-related oropharyngeal cancer in a classically low-burden region of southern Europe
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion