Uncovering de novo gene birth in yeast using deep transcriptomics

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  • dc.contributor.author Blevins, William Robert, 1987-
  • dc.contributor.author Ruiz Orera, Jorge, 1988-
  • dc.contributor.author Messeguer, Xavier
  • dc.contributor.author Blasco Moreno, Bernat, 1986-
  • dc.contributor.author Villanueva Cañas, José Luis, 1984-
  • dc.contributor.author Espinar, Lorena
  • dc.contributor.author Díez Antón, Juana, 1962-
  • dc.contributor.author Carey, Lucas, 1980-
  • dc.contributor.author Albà Soler, Mar
  • dc.date.accessioned 2021-02-16T07:02:16Z
  • dc.date.available 2021-02-16T07:02:16Z
  • dc.date.issued 2021
  • dc.description.abstract De novo gene origination has been recently established as an important mechanism for the formation of new genes. In organisms with a large genome, intergenic and intronic regions provide plenty of raw material for new transcriptional events to occur, but little is know about how de novo transcripts originate in more densely-packed genomes. Here, we identify 213 de novo originated transcripts in Saccharomyces cerevisiae using deep transcriptomics and genomic synteny information from multiple yeast species grown in two different conditions. We find that about half of the de novo transcripts are expressed from regions which already harbor other genes in the opposite orientation; these transcripts show similar expression changes in response to stress as their overlapping counterparts, and some appear to translate small proteins. Thus, a large fraction of de novo genes in yeast are likely to co-evolve with already existing genes.
  • dc.description.sponsorship The work was funded by grants PGC2018-094091-B-I00, BFU2015-65235-P, BFU2015-68351-P, BFU2016-80039-R, TIN2015-69175-C4-3-R and RTI2018-094403-B-C33 from Spanish Government—FEDER (EU), and from grant PT17/0009/0014 from Instituto de Salud Carlos III—FEDER. We also received funding from the “Maria de Maeztu” Programme for Units of Excellence in R&D (MDM-2014-0370) and from Agència de Gestió d’Ajuts Universitaris i de Recerca Generalitat de Catalunya (AGAUR), grants number 2014SGR1121, 2014SGR0974, 2017SGR1054 and 2017SGR01020 and, predoctoral fellowship (FI) to W.R.B.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Blevins WR, Ruiz-Orera J, Messeguer X, Blasco-Moreno B, Villanueva-Cañas JL, Espinar L, Díez J, Carey LB, Albà MM. Uncovering de novo gene birth in yeast using deep transcriptomics. Nat Commun. 2021; 12(1):604. DOI: 10.1038/s41467-021-20911-3
  • dc.identifier.doi http://dx.doi.org/10.1038/s41467-021-20911-3
  • dc.identifier.issn 2041-1723
  • dc.identifier.uri http://hdl.handle.net/10230/46484
  • dc.language.iso eng
  • dc.publisher Nature Research
  • dc.relation.ispartof Nat Commun. 2021; 12(1):604
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PGC2018-094091-B-I00
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2015-65235-P
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2015-68351-P
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2016-80039-R
  • dc.rights © The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Evolvability
  • dc.subject.keyword Fungal genetics
  • dc.subject.keyword Molecular evolution
  • dc.subject.keyword Transcriptomics
  • dc.title Uncovering de novo gene birth in yeast using deep transcriptomics
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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