Increases in Plasma Tryptophan Are Inversely Associated with Incident Cardiovascular Disease in the Prevención con Dieta Mediterránea (PREDIMED) Study

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  • dc.contributor.author Yu, Edwardca
  • dc.contributor.author Fitó Colomer, Montserratca
  • dc.contributor.author Martinez-Gonzalez, Miguel A.ca
  • dc.date.accessioned 2018-01-24T08:12:15Z
  • dc.date.available 2018-01-24T08:12:15Z
  • dc.date.issued 2017
  • dc.description.abstract Background: During development of cardiovascular disease (CVD), interferon-γ-mediated inflammation accelerates degradation of tryptophan into downstream metabolites. A Mediterranean diet (MedDiet) consisting of a high intake of extra-virgin olive oil (EVOO), nuts, fruits, vegetables, and cereals has been demonstrated to lower the risk of CVD. The longitudinal relation between tryptophan and its downstream metabolites and CVD in the context of a MedDiet is unstudied.Objective: We sought to investigate the relation between metabolites in the tryptophan-kynurenine pathway and CVD in the context of a MedDiet pattern.Methods: We used a case-cohort design nested in the Prevención con Dieta Mediterránea randomized controlled trial. There were 231 CVD cases (stroke, myocardial infarction, cardiovascular death) among 985 participants over a median of 4.7 y of follow-up [mean ± SD age: 67.6 ± 6.1 y; 53.7% women; mean ± SD body mass index (in kg/m2): 29.7 ± 3.7]. We assessed plasma tryptophan, kynurenine, kynurenic acid, 3-hydroxyanthranilic acid, and quinolinic acid concentrations at baseline and after 1 y of intervention with a MedDiet. We combined these metabolites in a kynurenine risk score (KRS) by weighting each metabolite by the adjusted coefficient of its associations with CVD. Cox models were used in the primary analysis.Results: Increases in tryptophan after 1 y were associated with a lower risk of composite CVD (HR per SD: 0.79; 95% CI: 0.63, 0.98). The baseline kynurenic acid concentration was associated with a higher risk of myocardial infarction and coronary artery disease death but not stroke. A higher KRS was more strongly associated with CVD in the control group than in the 2 intervention groups (P-interaction = 0.003). Adjustment for changes in plasma tryptophan attenuated the inverse association between MedDiet+EVOO and CVD.Conclusions: An increase in the plasma tryptophan concentration was significantly associated with a decreased risk of CVD. A MedDiet may counteract the deleterious effects of a high kynurenine risk score.
  • dc.description.sponsorship This study was funded by the National Institutes of Health of the United States (1R01HL118264), Spanish Ministry of Health (Instituto de Salud Carlos III) and the Ministerio de Economía y Competitividad-Fondo Europeo de Desarrollo Regional (Projects CNIC-06/2007, RTIC G03/140, CIBER 06/03, PI06-1326, PI07-0954, PI11/02505, SAF2009-12304 and AGL2010-22319-C03-03 ) and by the Generalitat Valenciana (ACOMP2010-181, AP111/10, AP-042/11, ACOM2011/145, ACOMP/2012/190, ACOMP/2013/159 and ACOMP/213/165)
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Yu E, Ruiz-Canela M, Guasch-Ferré M, Zheng Y, Toledo E4, Clish CB. Et al. Increases in Plasma Tryptophan Are Inversely Associated with Incident Cardiovascular Disease in the Prevención con Dieta Mediterránea (PREDIMED) Study. J Nutr. 2017 Mar;147(3):314-322. DOI: 10.3945/jn.116.241711
  • dc.identifier.doi http://dx.doi.org/10.3945/jn.116.241711
  • dc.identifier.issn 0022-3166
  • dc.identifier.uri http://hdl.handle.net/10230/33740
  • dc.language.iso eng
  • dc.publisher American Society for Nutritionca
  • dc.relation.ispartof Journal of Nutrition. 2017 Mar;147(3):314-22
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2009-12304
  • dc.rights c) 2016 American Society for Nutrition
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.subject.keyword Mediterranean diet
  • dc.subject.keyword Cardiovascular disease
  • dc.subject.keyword Epidemiology
  • dc.subject.keyword Metabolomics
  • dc.subject.keyword Nutrition
  • dc.subject.keyword Tryptophan
  • dc.subject.other Dieta -- Mediterrània, Regió de la
  • dc.subject.other Sistema cardiovascular -- Malalties
  • dc.title Increases in Plasma Tryptophan Are Inversely Associated with Incident Cardiovascular Disease in the Prevención con Dieta Mediterránea (PREDIMED) Studyca
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/acceptedVersion

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