Recent positive selection has acted on genes encoding proteins with more interactions within the whole human interactome

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• dc.contributor.author Luisi, Pierre, 1985-ca
• dc.contributor.author Álvarez Ponce, Davidca
• dc.contributor.author Pybus Oliveras, Marc, 1985-ca
• dc.contributor.author Fares, Mario A.ca
• dc.contributor.author Bertranpetit, Jaume, 1952-ca
• dc.contributor.author Laayouni, Hafid, 1968-ca
• dc.date.accessioned 2016-01-26T15:31:14Z
• dc.date.available 2016-01-26T15:31:14Z
• dc.date.issued 2015
• dc.description.abstract Genes vary in their likelihood to undergo adaptive evolution. The genomic factors that determine adaptability, however, remain poorly understood. Genes function in the context of molecular networks, with some occupying more important positions than others and thus being likely to be under stronger selective pressures. However, how positive selection distributes across the different parts of molecular networks is still not fully understood. Here, we inferred positive selection using comparative genomics and population genetics approaches through the comparison of 10 mammalian and 270 human genomes, respectively. In agreement with previous results, we found that genes with lower network centralities are more likely to evolve under positive selection (as inferred from divergence data). Surprisingly, polymorphism data yield results in the opposite direction than divergence data: Genes with higher centralities are more likely to have been targeted by recent positive selection during recent human evolution. Our results indicate that the relationship between centrality and the impact of adaptive evolution highly depends on the mode of positive selection and/or the evolutionary time-scale.ca
• dc.description.sponsorship This work was funded by the “Ministerio de Ciencia y Tecnología” (Spain) (grant BFU2013-43726-P), and the “Direcció General de Recerca, Generalitat de Catalunya (Grup de Recerca Consolidat 2009 SGR 1101)” awarded to J.B. P.L. was supported by a Ph.D. fellowship from “Acción Estratégica de Salud, en el marco del Plan Nacional de Investigación Científica, Desarrollo e Innovación Tecnológica 2008–2011” from Instituto de Salud Carlos III. D.A.-P. was a “Juan de la Cierva” fellow from the “Ministerio de Economía y Competitividad” (Spain) (JCI-2011-11089). M.A.F. was supported by a Principal Investigator grant from Science Foundation Ireland (12/IP/1673) and a project from the “Ministerio de Economía y Competitividad” (grant number BFU2012-36346).
• dc.format.mimetype application/pdfca
• dc.identifier.citation Luisi P, Alvarez-Ponce D, Pybus M, Fares MA, Bertranpetit J, Laayouni H. Recent positive selection has acted on genes encoding proteins with more interactions within the whole human interactome. Genome biology and evolution. 2015;7(4):1141-54. DOI: 10.1093/gbe/evv055ca
• dc.identifier.doi http://dx.doi.org/10.1093/gbe/evv055
• dc.identifier.issn 1759-6653
• dc.identifier.uri http://hdl.handle.net/10230/25663
• dc.language.iso engca
• dc.publisher Oxford University Pressca
• dc.relation.ispartof Genome biology and evolution. 2015;7(4):1141-54
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2013-43726
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/JCI2011-11089
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2012-36346
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2013-43726-P
• dc.rights © The Author(s) 2015. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.ca
• dc.rights.accessRights info:eu-repo/semantics/openAccessca
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/ca
• dc.subject.keyword Physical protein interaction
• dc.subject.keyword Protein interaction network
• dc.subject.keyword Natural selection
• dc.subject.keyword Positive selection
• dc.subject.keyword Mammals
• dc.subject.keyword Humans
• dc.subject.other Genoma humàca
• dc.subject.other Proteïnesca
• dc.title Recent positive selection has acted on genes encoding proteins with more interactions within the whole human interactomeca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/publishedVersionca