Arsenic exposure and respiratory outcomes during childhood in the INMA study

Mostra el registre complet Registre parcial de l'ítem

• dc.contributor.author Signes-Pastor, Antonio J.
• dc.contributor.author Díaz-Coto, Susana
• dc.contributor.author Martinez-Camblor, Pablo
• dc.contributor.author Carey, Manus
• dc.contributor.author Soler Blasco, Raquel
• dc.contributor.author García-Villarino, Miguel
• dc.contributor.author Fernández-Somoano, Ana
• dc.contributor.author Júlvez Calvo, Jordi
• dc.contributor.author Carrasco, Paula
• dc.contributor.author Lertxundi, Aitana
• dc.contributor.author Santa Marina, Loreto
• dc.contributor.author Casas Sanahuja, Maribel
• dc.contributor.author Meharg, Andrew A.
• dc.contributor.author Karagas, Margaret R.
• dc.contributor.author Vioque, Jesus
• dc.date.accessioned 2022-12-22T08:31:35Z
• dc.date.available 2022-12-22T08:31:35Z
• dc.date.issued 2022
• dc.description.abstract Ingested inorganic arsenic (iAs) is a human carcinogen that is also linked to other adverse health effects, such as respiratory outcomes. Yet, among populations consuming low-arsenic drinking water, the impact of iAs exposure on childhood respiratory health is still uncertain. For a Spanish child study cohort (INfancia y Medio Ambiente-INMA), low-arsenic drinking water is usually available and ingestion of iAs from food is considered the major source of exposure. Here, we explored the association between iAs exposure and children's respiratory outcomes assessed at 4 and 7 years of age (n = 400). The summation of 4-year-old children's urinary iAs, monomethylarsonic acid (MMA), and dimethylarsinic acid (DMA) was used as a biomarker of iAs exposure (∑As) (median of 4.92 μg/L). Children's occurrence of asthma, eczema, sneeze, wheeze, and medication for asthma and wheeze at each assessment time point (i.e., 4- and 7-year) was assessed with maternal interviewer-led questionnaires. Crude and adjusted Poisson regression models using Generalized Estimating Equation (GEE) were performed to account for the association between natural logarithm transformed (ln) urinary ∑As in μg/L at 4 years and repeated assessments of respiratory symptoms at 4 and 7 years of age. The covariates included in the models were child sex, maternal smoking status, maternal level of education, sub-cohort, and children's consumption of vegetables, fruits, and fish/seafood. The GEE-splines function using Poisson regression showed an increased trend of the overall expected counts of respiratory symptoms with high urinary ∑As. The adjusted expected counts (95% confidence intervals) at ln-transformed urinary ∑As 1.57 (average concentration) and 4.00 (99th percentile concentration) were 0.63 (0.36, 1.10) and 1.33 (0.61, 2.89), respectively. These exploratory findings suggest that even relatively low-iAs exposure levels, relevant to the Spanish and other populations, may relate to an increased number of respiratory symptoms during childhood.
• dc.format.mimetype application/pdf
• dc.identifier.citation Signes-Pastor AJ, Díaz-Coto S, Martinez-Camblor P, Carey M, Soler-Blasco R, García-Villarino M, Fernández-Somoano A, Julvez J, Carrasco P, Lertxundi A, Santa Marina L, Casas M, Meharg AA, Karagas MR, Vioque-Lopez J. Arsenic exposure and respiratory outcomes during childhood in the INMA study. PLoS One. 2022 Sep 9;17(9):e0274215. DOI: 10.1371/journal.pone.0274215
• dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0274215
• dc.identifier.issn 1932-6203
• dc.identifier.uri http://hdl.handle.net/10230/55208
• dc.language.iso eng
• dc.publisher Public Library of Science (PLoS)
• dc.relation.ispartof PLoS One. 2022 Sep 9;17(9):e0274215
• dc.rights © 2022 Signes-Pastor et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Arsenic
• dc.subject.keyword Asthma
• dc.subject.keyword Pediatrics
• dc.subject.keyword Sneezing
• dc.subject.keyword Urine
• dc.subject.keyword Eczema
• dc.subject.keyword Children
• dc.subject.keyword Urology
• dc.title Arsenic exposure and respiratory outcomes during childhood in the INMA study
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion