Seasonal variations in the onset of positive and negative renal ANCA-associated vasculitis in Spain

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  • dc.contributor.author Draibe, Juliana
  • dc.contributor.author Rodo, Xavier
  • dc.contributor.author Fulladosa, Xavier
  • dc.contributor.author Martínez-Valenzuela, Laura
  • dc.contributor.author Diaz-Encarnación, Montserrat
  • dc.contributor.author Santos, Lara
  • dc.contributor.author Marco, Helena
  • dc.contributor.author Quintana, Luis
  • dc.contributor.author Rodriguez García, Eva
  • dc.contributor.author Barros, Xoana
  • dc.contributor.author García, Rosa
  • dc.contributor.author Balius, Anna
  • dc.contributor.author Cruzado, Josep Ma.
  • dc.contributor.author Torras, Joan
  • dc.contributor.author Grup de Malalties Glomerulars de la Societat Catalana de Nefrologia (GLOMCAT)
  • dc.date.accessioned 2019-03-28T07:38:58Z
  • dc.date.available 2019-03-28T07:38:58Z
  • dc.date.issued 2018
  • dc.description.abstract BACKGROUND: The closure of long-standing gaps in our knowledge of aetiological factors behind anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a major challenge. Descriptive and analytical epidemiological studies can improve our understanding of environmental influences. Reported seasonal variations in AAV, mainly related to Wegener's disease, have shown an increasing number of cases in the winter months, which could be related to an extrinsic factor underlying infection. The objective of this paper was to study seasonal variations in AAV with respect to renal affectation diagnosed in Catalonia, Spain. METHODS: Two hundred and thirty-four patients diagnosed for renal AAV between 2001 and 2014 in eight hospitals in Catalonia were included in the study. We used medical records to retrospectively analyse the date of the first symptoms attributed to the AAV, ANCA subtypes, the degree of renal impairment and renal histology. RESULTS: Of the 234 patients studied, 49.2% were male and 50.8% female. For ANCA status, 8.5% were positive, 15.9% were proteinase-3-positive and 75.6% were myeloperoxidase-positive. In relation to histological classification, 17.8% were sclerotic, 11.7% focal, 38.8% crescentic and 31.7% mixed. Regarding seasonal distribution, we observed a clear seasonal periodicity with a significantly higher incidence of cases in the winter. Applying an Eigen decomposition, we observed a periodic fluctuation of frequencies around the annual cycle with peaks every 10-12 months, and higher incidence of AAV cases in February. CONCLUSIONS: Our results confirm, in Catalonia, the seasonal periodicity of AAV with a higher incidence in the winter, as formerly described in the literature for other regions. An environmental factor, likely one that is infectious, may explain this finding.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Draibe J, Rodó X, Fulladosa X, Martínez-Valenzuela L, Diaz-Encarnación M, Santos L. et al. Seasonal variations in the onset of positive and negative renal ANCA-associated vasculitis in Spain. Clin Kidney J. 2018 Aug;11(4):468-473. DOI: 10.1093/ckj/sfx127
  • dc.identifier.doi http://dx.doi.org/10.1093/ckj/sfx127
  • dc.identifier.issn 2048-8505
  • dc.identifier.uri http://hdl.handle.net/10230/36992
  • dc.language.iso eng
  • dc.publisher Oxford University Press
  • dc.relation.ispartof Clinical Kidney Journal. 2018 Aug;11(4):468-73
  • dc.rights © The Author 2017. Published by Oxford University Press on behalf of ERA-EDTA. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
  • dc.subject.keyword Vasculitis
  • dc.subject.keyword ANCA
  • dc.subject.keyword Epidemiology
  • dc.subject.keyword Immunology
  • dc.subject.keyword Seasonal
  • dc.subject.keyword Seasonality
  • dc.subject.other Vasculitis -- Espanya
  • dc.title Seasonal variations in the onset of positive and negative renal ANCA-associated vasculitis in Spain
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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Articles (Hospital del Mar Research Institute)
Articles (Barcelona Institute for Global Health (ISGlobal) – Campus Mar)