Early-life environmental exposure determinants of child behavior in Europe: A longitudinal, population-based study

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• dc.contributor.author Maitre, Léa
• dc.contributor.author Júlvez Calvo, Jordi
• dc.contributor.author López Vicente, Mònica, 1988-
• dc.contributor.author Warembourg, Charline
• dc.contributor.author Tamayo-Uria, Ibon
• dc.contributor.author Guxens Junyent, Mònica
• dc.contributor.author Basagaña Flores, Xavier
• dc.contributor.author Casas Sanahuja, Maribel
• dc.contributor.author de Castro, Montserrat
• dc.contributor.author González, Juan Ramón
• dc.contributor.author Hernandez-Ferrer, Carles, 1987-
• dc.contributor.author Márquez, Sandra
• dc.contributor.author Nieuwenhuijsen, Mark J.
• dc.contributor.author Urquiza, José M.
• dc.contributor.author Vrijheid, Martine
• dc.date.accessioned 2022-05-05T05:50:58Z
• dc.date.available 2022-05-05T05:50:58Z
• dc.date.issued 2021
• dc.description.abstract Background: Environmental exposures in early life influence the development of behavioral outcomes in children, but research has not considered multiple exposures. We therefore aimed to investigate the impact of a broad spectrum of pre- and postnatal environmental exposures on child behavior. Methods and findings: We used data from the HELIX (Human Early Life Exposome) project, which was based on six longitudinal population-based birth cohorts in Europe. At 6-11 years, children underwent a follow-up to characterize their exposures and assess behavioral problems. We measured 88 prenatal and 123 childhood environmental factors, including outdoor, indoor, chemical, lifestyle and social exposures. Parent-reported behavioral problems included (1) internalizing, (2) externalizing scores, using the child behavior checklist (CBCL), and (3) the Conner's Attention Deficit Hyperactivity Disorder (ADHD) index, all outcomes being discrete raw counts. We applied LASSO penalized negative binomial regression models to identify which exposures were associated with the outcomes, while adjusting for co-exposures. In the 1287 children (mean age 8.0 years), 7.3% had a neuropsychiatric medical diagnosis according to parent's reports. During pregnancy, smoking and car traffic showing the strongest associations (e.g. smoking with ADHD index, aMR:1.31 [1.09; 1.59]) among the 13 exposures selected by LASSO, for at least one of the outcomes. During childhood, longer sleep duration, healthy diet and higher family social capital were associated with reduced scores whereas higher exposure to lead, copper, indoor air pollution, unhealthy diet were associated with increased scores. Unexpected decreases in behavioral scores were found with polychlorinated biphenyls (PCBs) and organophosphate (OP) pesticides. Conclusions: Our systematic exposome approach identified several environmental contaminants and healthy lifestyle habits that may influence behavioral problems in children. Modifying environmental exposures early in life may limit lifetime mental health risk.
• dc.description.sponsorship The LIFE-CYCLE project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 733206.
• dc.format.mimetype application/pdf
• dc.identifier.citation Maitre L, Julvez J, López-Vicente M, Warembourg C, Tamayo-Uria I, Philippat C et al. Early-life environmental exposure determinants of child behavior in Europe: A longitudinal, population-based study. Environ Int. 2021 Aug;153:106523. DOI: 10.1016/j.envint.2021.106523
• dc.identifier.doi http://dx.doi.org/10.1016/j.envint.2021.106523
• dc.identifier.issn 0160-4120
• dc.identifier.uri http://hdl.handle.net/10230/52984
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Environ Int. 2021 Aug;153:106523
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/733206
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/308333
• dc.rights © 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.subject.keyword ADHD
• dc.subject.keyword Behavioural problems
• dc.subject.keyword CBCL
• dc.subject.keyword Chemicals
• dc.subject.keyword Children
• dc.subject.keyword Cohort
• dc.subject.keyword Environment
• dc.subject.keyword Epidemiology
• dc.subject.keyword Exposome
• dc.subject.keyword Pollutants
• dc.title Early-life environmental exposure determinants of child behavior in Europe: A longitudinal, population-based study
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion