Comparison of autofluorescence and white-light bronchoscopies performed with the Evis Lucera Spectrum for the detection of bronchial cancers: a meta-analysis

Sun, Shuangshuang; Yang, Yang; Chen, Meizi; Wang, Li; Pan, Hangcheng; Zhang,  Xiuwei; Wagnieres, Georges; Mohammad, Yousser; Barreiro Portela, Esther; Pirozzolo, Giovanni; Villeneuve, P. James; Zhan, Ping; Wan, Bing; AME Lung Cancer Collaborative Group

Comparison of autofluorescence and white-light bronchoscopies performed with the Evis Lucera Spectrum for the detection of bronchial cancers: a meta-analysis

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dc.contributor.author Sun, Shuangshuang
dc.contributor.author Yang, Yang
dc.contributor.author Chen, Meizi
dc.contributor.author Wang, Li
dc.contributor.author Pan, Hangcheng
dc.contributor.author Zhang, Xiuwei
dc.contributor.author Wagnieres, Georges
dc.contributor.author Mohammad, Yousser
dc.contributor.author Barreiro Portela, Esther
dc.contributor.author Pirozzolo, Giovanni
dc.contributor.author Villeneuve, P. James
dc.contributor.author Zhan, Ping
dc.contributor.author Wan, Bing
dc.contributor.author AME Lung Cancer Collaborative Group
dc.date.accessioned 2020-06-23T06:58:33Z
dc.date.available 2020-06-23T06:58:33Z
dc.date.issued 2020
dc.description.abstract Background: Many recent studies have reported that autofluorescence bronchoscopy (AFB) has a superior sensitivity and decreased specificity in the diagnosis of bronchial cancers when compared with white-light bronchoscopy (WLB). We specifically analyzed the diagnostic performances of autofluorescence imaging video bronchoscopy (AFI) performed with the Evis Lucera Spectrum from Olympus, which is a relatively novel approach in detecting and delineating bronchial cancers, and compared it to the older WLB method. Methods: We searched the PubMed, Embase, Web of Science, and CNKI databases from inception to July 12th, 2018 for trials in which patients were diagnosed with lung cancer via concurrent or combined use of AFI and WLB. The included studies were required to have a histologic diagnosis as the gold standard comparison, and a sufficient amount of data was extracted to assess the diagnostic capacity. A 2×2 table was constructed, and the area under the receiver-operating characteristic curve (AUC) of AFI and WLB was estimated by using a stochastic model for diagnostic meta-analysis using STATA software. Results: A total of 10 articles were eligible for the meta analysis, comprising 1,830 patients with complete data included in the analysis. AFI showed a superior sensitivity of 0.92 (95% CI, 0.88-0.95) over WLB's 0.70 (95% CI, 0.58-0.80) with P<0.01, and a comparable specificity of 0.67 (95% CI, 0.51-0.80) compared with WLB's 0.78 (95% CI, 0.68-0.86) with P=0.056. Egger's test P value (0.225) demonstrated that there was no publication bias. Conclusions: Our research showed that in the evaluation of bronchial cancers, AFI was superior to conventional WLB. With its higher sensitivity, AFI could be valuable for avoiding misdiagnosis.
dc.format.mimetype application/pdf
dc.identifier.citation Sun S, Yang Y, Chen M, Wang L, Pan H, Zhang X, et al. Comparison of autofluorescence and white-light bronchoscopies performed with the Evis Lucera Spectrum for the detection of bronchial cancers: a meta-analysis. Transl Lung Cancer Res. 2020 Feb; 9(1):23-32. DOI: 10.21037/tlcr.2020.01.04
dc.identifier.doi http://dx.doi.org/10.21037/tlcr.2020.01.04
dc.identifier.issn 2218-6751
dc.identifier.uri http://hdl.handle.net/10230/45026
dc.language.iso eng
dc.publisher Pioneer Bioscience Publishing Company
dc.rights This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the noncommercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-ncnd/4.0/.
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by-ncnd/4.0/
dc.subject.keyword Autofluorescence bronchoscopy (AFB)
dc.subject.keyword Evis Lucera Spectrum
dc.subject.keyword Bronchial cancer
dc.subject.keyword Meta-analysis
dc.subject.keyword White-light bronchoscopy (WLB)
dc.title Comparison of autofluorescence and white-light bronchoscopies performed with the Evis Lucera Spectrum for the detection of bronchial cancers: a meta-analysis
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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