Multi-receptor binding profile of clozapine and olanzapine: a structural study based on the new beta (2) adrenergic receptor template

Citació

  • Selent J, López L, Sanz F, Pastor M. Multi-Receptor Binding Profile of Clozapine and Olanzapine: A Structural Study Based on the New β2 Adrenergic Receptor Template. ChemMedChem. 2008;3(8):1194-8. DOI: 10.1002/cmdc.200800074

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  • Resum

    Schizophrenia is a devastating mental disorder that has a large/nimpact on the quality of life for those who are afflicted and is/nvery costly for families and society.[1] Although the etiology of/nschizophrenia is still unknown and no cure has yet been/nfound, it is treatable, and pharmacological therapy often produces/nsatisfactory results. Among the various antipsychotic/ndrugs in use, clozapine is widely recognized as one ofthe/nmost clinically effective agents, even if it elicits significant side/neffects such as metabolic disorders and agranulocytosis. Clozapine/nand the closely related compound olanzapine are good/nexamples ofdrug s with a complex multi-receptor profile ;[2]/nthey have affinities toward serotonin, dopamine, a adrenergic,/nmuscarinic, and histamine receptors, among others.
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