Age of Onset and Lifetime Projected Risk of Psychotic Experiences: Cross-National Data From the World Mental Health Survey.

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  • dc.contributor.author McGrath, John J.ca
  • dc.contributor.author Alonso Caballero, Jordica
  • dc.contributor.author Kessler, Ronald C.ca
  • dc.date.accessioned 2016-07-29T07:50:54Z
  • dc.date.issued 2016
  • dc.description.abstract BACKGROUND: Given the early age of onset (AOO) of psychotic disorders, it has been assumed that psychotic experiences (PEs) would have a similar early AOO. The aims of this study were to describe (a) the AOO distribution of PEs, (b) the projected lifetime risk of PEs, and (c) the associations of PE AOO with selected PE features. METHODS: Data came from the WHO World Mental Health (WMH) surveys. A total of 31 261 adult respondents across 18 countries were assessed for lifetime prevalence of PE. Projected lifetime risk (at age 75 years) was estimated using a 2-part actuarial method. AOO distributions were described for the observed and projected estimates. We examined associations of AOO with PE type metric and annualized PE frequency. RESULTS: Projected lifetime risk for PEs was 7.8% (SE = 0.3), slightly higher than lifetime prevalence (5.8%, SE = 0.2). The median (interquartile range; IQR) AOO based on projected lifetime estimates was 26 (17-41) years, indicating that PEs commence across a wide age range. The AOO distributions for PEs did not differ by sex. Early AOO was positively associated with number of PE types (F = 14.1, P < .001) but negatively associated with annualized PE frequency rates (F = 8.0, P < .001). DISCUSSION: While most people with lifetime PEs have first onsets in adolescence or young adulthood, projected estimates indicate that nearly a quarter of first onsets occur after age 40 years. The extent to which late onset PEs are associated with (a) late onset mental disorders or (b) declining cognitive and/or sensory function need further researchca
  • dc.description.sponsorship Each World Mental Health (WMH) country obtained funding for its own survey. The Sao Paulo Megacity Mental Health Survey is supported by Thematic Project Grant 03/00 204-3 from the State of Sao Paulo Research Foundation; the Shenzhen Mental Health Survey, by the Shenzhen Bureau of Health and the Shenzhen Bureau of Science, Technology, and Information; the Colombian National Study of Mental Health, by the Ministry of Social Protection and the Saldarriaga Concha Foundation; the European Study of the Epidemiology of Mental Disorders project, by contracts QLG5-1999- 01042 and 2004123 from the European Commission, the Fondo de Investigacion Sanitaria (the Piedmont Region [Italy]), grant FIS 00/0028 from the Instituto de Salud Carlos III (Spain), grant SAF 2000-158-CE from the Ministerio de Ciencia y Tecnologia (Spain), grants Centro de Investigacion Biomedica en Red CB06/02/0046 and Redes Tematicas de Investigacion Cooperativa en Salud RD06/0011 REM-TAP from the Departament de Salut, Generalitat de Catalunya, Spain, Instituto de Salud Carlos III, other local agencies, and an unrestricted educational grant from GlaxoSmithKline; the Iraq Mental Health Survey (IMHS), by funding from the Japanese and European funds through United Nations Development Group Iraq Trust Fund; the Lebanese National Mental Health Survey, by the Lebanese Ministry of Public Health, the World Health Organization (WHO) (Lebanon), anonymous private donations to the Institute for Development, Research, Advocacy and Applied Care, Lebanon, and unrestricted grants from Janssen Cilag, Eli Lilly and Company, GlaxoSmithKline, Roche, and approval of the manuscript; and decision to submit the manuscript for publication
  • dc.format.mimetype application/pdfca
  • dc.identifier.citation McGrath JJ, Saha S, Al-Hamzawi AO, Alonso J, Andrade L, Borges G. et al. Age of Onset and Lifetime Projected Risk of Psychotic Experiences: Cross-National Data From the World Mental Health Survey. Schizophr Bull. 2016 Jul;42(4):933-41. doi: 10.1093/schbul/sbw011ca
  • dc.identifier.doi http://dx.doi.org/10.1093/schbul/sbw011
  • dc.identifier.issn 0586-7614
  • dc.identifier.uri http://hdl.handle.net/10230/27247
  • dc.language.iso engca
  • dc.publisher Oxford University Pressca
  • dc.relation.ispartof Schizophrenia Bulletin. 2016 Jul;42(4):933-41
  • dc.rights © Oxford University Press. This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Schizophrenia Bulletin following peer review. The definitive publisher-authenticated version McGrath JJ, Saha S, Al-Hamzawi AO, Alonso J, Andrade L, Borges G. et al. Age of Onset and Lifetime Projected Risk of Psychotic Experiences: Cross-National Data From the World Mental Health Survey. Schizophr Bull. 2016 Jul;42(4):933-41, is available online at: http://de.doi.org/10.1093/schbul/sbw011ca
  • dc.rights.accessRights info:eu-repo/semantics/openAccessca
  • dc.subject.other Salut mentalca
  • dc.subject.other Malalties mentalsca
  • dc.title Age of Onset and Lifetime Projected Risk of Psychotic Experiences: Cross-National Data From the World Mental Health Survey.ca
  • dc.type info:eu-repo/semantics/articleca
  • dc.type.version info:eu-repo/semantics/acceptedVersionca

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