Joint analysis of morphological parameters and in silico haemodynamics of the left atrial appendage for thrombogenic risk assessment

Mostra el registre complet Registre parcial de l'ítem

  • dc.contributor.author Pons Vidal, Maria Isabel
  • dc.contributor.author Mill, Jordi
  • dc.contributor.author Fernandez-Quilez, Álvaro
  • dc.contributor.author Olivares, Andy L.
  • dc.contributor.author Silva, Etelvino
  • dc.contributor.author De Potter, Tom
  • dc.contributor.author Camara, Oscar
  • dc.date.accessioned 2023-02-15T07:24:22Z
  • dc.date.available 2023-02-15T07:24:22Z
  • dc.date.issued 2022
  • dc.description.abstract Background. Atrial fibrillation (AF) is considered the most common human arrhythmia. In nonvalvular AF, around 99% of thrombi are formed in the left atrial appendage (LAA). Nevertheless, there is not a consensus in the community about the relevant factors to stratify the AF population according to thrombogenic risk. Objective. To demonstrate the need for combining left atrial morphological and haemodynamics indices to improve the thrombogenic risk assessment in nonvalvular AF patients. Methods. A cohort of 71 nonvalvular AF patients was analysed. Statistical analysis, regression models, and random forests were used to analyse the differences between morphological and haemodynamics parameters, extracted from computational simulations built on 3D rotational angiography images, between patients with and without transient ischemic attack (TIA) or cerebrovascular accident (CVA). Results. The analysis showed that models composed of both morphological and haemodynamic factors were better predictors of TIA/CVA compared with models based on either morphological or haemodynamic factors separately. Maximum ostium diameter, length of the centreline, blood flow velocity within the LAA, oscillatory shear index, and time average wall shear stress parameters were found to be key risk factors for TIA/CVA prediction. In addition, TIA/CVA patients presented more flow stagnation within the LAA. Conclusion. Thrombus formation in the LAA is the result of multiple factors. Analyses based only on morphological or haemodynamic parameters are not precise enough to predict such a phenomenon, as demonstrated in our results; a better patient stratification can be obtained by jointly analysing morphological and haemodynamic features.
  • dc.description.sponsorship This work was supported by the Spanish Ministry of Science, Innovation and Universities under the Retos I+D Programme (RTI2018-101193-B-I00), the Maria de Maeztu Units of Excellence Programme (MDM-2015-0502), the Spanish Ministry of Economy and Competitiveness under the Programme for the Formation of Doctors (PRE2018-084062), and MINECO (RYC-2015-18888).
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Pons MI, Mill J, Fernandez-Quilez A, Olivares AL, Silva E, de Potter T, Camara O. Joint analysis of morphological parameters and in silico haemodynamics of the left atrial appendage for thrombogenic risk assessment. J Interv Cardiol. 2022;2022:9125224. DOI: 10.1155/2022/9125224
  • dc.identifier.doi http://dx.doi.org/10.1155/2022/9125224
  • dc.identifier.issn 0896-4327
  • dc.identifier.uri http://hdl.handle.net/10230/55774
  • dc.language.iso eng
  • dc.publisher Hindawi
  • dc.relation.ispartof Journal of Interventional Cardiology. 2022;2022:9125224.
  • dc.relation.isreferencedby https://downloads.hindawi.com/journals/jitc/2022/9125224.f1.docx
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/RTI2018-101193-B-I00
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PRE2018-084062
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/RYC-2015-18888
  • dc.rights © 2022 Maria Isabel Pons et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.other Flux sanguini
  • dc.subject.other Avaluació del risc
  • dc.subject.other Ecocardiografia--Metodologia
  • dc.title Joint analysis of morphological parameters and in silico haemodynamics of the left atrial appendage for thrombogenic risk assessment
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

Col·leccions

Articles (Departament de Tecnologies de la Informació i les Comunicacions)