Determinants of metastatic competency in colorectal cancer
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- dc.contributor.author Tauriello, Daniele V.F.ca
- dc.contributor.author Calon, Alexandreca
- dc.contributor.author Lonardo, Enzaca
- dc.contributor.author Batlle Gómez, Eduardca
- dc.date.accessioned 2018-01-30T08:45:09Z
- dc.date.available 2018-01-30T08:45:09Z
- dc.date.issued 2017
- dc.description.abstract Colorectal cancer (CRC) is one of the most common cancer types and represents a major therapeutic challenge. Although initial events in colorectal carcinogenesis are relatively well characterized and treatment for early-stage disease has significantly improved over the last decades, the mechanisms underlying metastasis - the main cause of death - remain poorly understood. Correspondingly, no effective therapy is currently available for advanced or metastatic disease. There is increasing evidence that colorectal cancer is hierarchically organized and sustained by cancer stem cells, in concert with various stromal cell types. Here, we review the interplay between cancer stem cells and their microenvironment in promoting metastasis and discuss recent insights relating to both patient prognosis and novel targeted treatment strategies. A better understanding of these topics may aid the prevention or reduction of metastatic burden
- dc.description.sponsorship Work by the authors has been supported by grant SAF2014-53784_R (EB) and Juan de la Cierva fellowships (DVFT and AC) from the Spanish Ministry of Economy and Competitiveness (MINECO), by fellowships from Fundacion Olga Torres (EL) and Asociacion Española contra el Cancer (EL) and by the Dr. Josef Steiner Foundation (EB). Work in the laboratory of EB is supported by Fundacion Botín and Banco Santander, through Santander Universities. IRB Barcelona is the recipient of a Severo Ochoa Award of Excellence from the MINECO. We would like to thank members of the laboratory of EB for fruitful discussions
- dc.format.mimetype application/pdf
- dc.identifier.citation Tauriello DV, Calon A, Lonardo E, Batlle E. Determinants of metastatic competency in colorectal cancer. Mol Oncol. 2017 Jan;11(1):97-119. DOI: 10.1002/1878-0261.12018
- dc.identifier.doi http://dx.doi.org/10.1002/1878-0261.12018
- dc.identifier.issn 1574-7891
- dc.identifier.uri http://hdl.handle.net/10230/33780
- dc.language.iso eng
- dc.publisher Wileyca
- dc.relation.ispartof Molecular Cancer. 2017 Jan;11(1):97-119
- dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2014-53784_R
- dc.rights Copyright © 2016 The Authors. Published by FEBS Press and John Wiley & Sons Ltd. This is an open access article under the terms of the https://creativecommons.org/licenses/by/4.0/, which permits use, distribution and reproduction in any medium, provided the original work is properly cited
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Heterogeneity
- dc.subject.keyword TGF-beta
- dc.subject.keyword ancer immunology
- dc.subject.keyword Cancer stem cells
- dc.subject.keyword Clonal diversity
- dc.subject.keyword Combination therapy
- dc.subject.keyword Dormancy
- dc.subject.keyword Immunotherapy
- dc.subject.keyword Stroma
- dc.subject.keyword Tumour microenvironment
- dc.title Determinants of metastatic competency in colorectal cancerca
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion