Role of the NUDT enzymes in breast cancer

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  • dc.contributor.author Wright, Roni H.G.
  • dc.contributor.author Beato, Miguel
  • dc.date.accessioned 2021-03-18T09:17:29Z
  • dc.date.available 2021-03-18T09:17:29Z
  • dc.date.issued 2021
  • dc.description.abstract Despite global research efforts, breast cancer remains the leading cause of cancer death in women worldwide. The majority of these deaths are due to metastasis occurring years after the initial treatment of the primary tumor and occurs at a higher frequency in hormone receptor-positive (Estrogen and Progesterone; HR+) breast cancers. We have previously described the role of NUDT5 (Nudix-linked to moiety X-5) in HR+ breast cancer progression, specifically with regards to the growth of breast cancer stem cells (BCSCs). BCSCs are known to be the initiators of epithelial-to-mesenchyme transition (EMT), metastatic colonization, and growth. Therefore, a greater understanding of the proteins and signaling pathways involved in the metastatic process may open the door for therapeutic opportunities. In this review, we discuss the role of NUDT5 and other members of the NUDT family of enzymes in breast and other cancer types. We highlight the use of global omics data based on our recent phosphoproteomic analysis of progestin signaling pathways in breast cancer cells and how this experimental approach provides insight into novel crosstalk mechanisms for stratification and drug discovery projects aiming to treat patients with aggressive cancer.
  • dc.description.sponsorship The experimental part of this review was supported by Grants from ERC (Project “4D Genome” 609989 and Project “Impacct” 825176), the Spanish Ministery of Science (G62426937) and the Generalitat de Catalunya (AGAUR SGR 757, 2019PROD00115 and INNOV 00036) and the CRG
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Wright RHG, Beato M. Role of the NUDT enzymes in breast cancer. Int J Mol Sci. 2021 Feb 25; 22(5): 2267. DOI: 10.3390/ijms22052267
  • dc.identifier.doi http://dx.doi.org/10.3390/ijms22052267
  • dc.identifier.issn 1422-0067
  • dc.identifier.uri http://hdl.handle.net/10230/46838
  • dc.language.iso eng
  • dc.publisher MDPI
  • dc.relation.ispartof International Journal of Molecular Sciences. 2021 Feb 25;22(5):2267
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/609989
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/825176
  • dc.rights © 2021 by the Roni H.G. Wright and Miguel Beato. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri https://creativecommons.org/licenses/by/4.0/
  • dc.subject.other Mama -- Càncer
  • dc.subject.other Enzims
  • dc.title Role of the NUDT enzymes in breast cancer
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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