Red blood cell eicosapentaenoic acid inversely relates to MRI-assessed carotid plaque lipid core burden in elders at high cardiovascular risk

Bargallo, Nuria; Gilabert, Rosa; Romero-Mamani, Edwin-Saúl; Cofán, Montserrat; Calder, Philip  C.; Fitó Colomer, Montserrat; Corella, Dolores; Salas-Salvadó, Jordi; Ruiz-Canela, Miguel; Estruch, Ramón; Ros, Emilio; Sala Vila, Aleix

Red blood cell eicosapentaenoic acid inversely relates to MRI-assessed carotid plaque lipid core burden in elders at high cardiovascular risk

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dc.contributor.author Bargallo, Nuriaca
dc.contributor.author Gilabert, Rosaca
dc.contributor.author Romero-Mamani, Edwin-Saúlca
dc.contributor.author Cofán, Montserratca
dc.contributor.author Calder, Philip C.ca
dc.contributor.author Fitó Colomer, Montserratca
dc.contributor.author Corella, Doloresca
dc.contributor.author Salas-Salvadó, Jordica
dc.contributor.author Ruiz-Canela, Miguelca
dc.contributor.author Estruch, Ramónca
dc.contributor.author Ros, Emilioca
dc.contributor.author Sala Vila, Aleixca
dc.date.accessioned 2018-07-06T06:56:30Z
dc.date.available 2018-07-06T06:56:30Z
dc.date.issued 2017
dc.description.abstract Supplemental marine omega-3 eicosapentaenoic acid (EPA) has an anti-atherosclerotic effect. Clinical research on EPA supplied by the regular diet and atherosclerosis is scarce. In the framework of the PREvención con DIeta MEDiterránea (PREDIMED) trial, we conducted a cross-sectional study in 161 older individuals at high vascular risk grouped into different stages of carotid atherosclerosis severity, including those without ultrasound-detected atheroma plaque (n = 38), with plaques <2.0 mm thick (n = 65), and with plaques ≥2.0 mm (n = 79). The latter were asked to undergo contrast-enhanced 3T magnetic resonance imaging (MRI) and were subsequently grouped into absence (n = 31) or presence (n = 27) of MRI-detectable plaque lipid, a main feature of unstable atheroma plaques. We determined the red blood cell (RBC) proportion of EPA (a valid marker of long-term EPA intake) at enrolment by gas chromatography. In multivariate models, EPA related inversely to MRI-assessed plaque lipid volume, but not to maximum intima-media thickness of internal carotid artery, plaque burden, or MRI-assessed normalized wall index. The inverse association between EPA and plaque lipid content in patients with advanced atherosclerosis supports the notion that this fatty acid might improve cardiovascular health through stabilization of advanced atheroma plaques.
dc.description.sponsorship CIBEROBN is an initiative of ISCIII, Spain. This study was funded in part by ISCIII (Spanish Ministry of Economy) through grants RTIC G03/140, RTIC RD 06/0045, Centro Nacional de Investigaciones Cardiovasculares CNIC 06/2007, ISCIII FIS PS09/01292; the Spanish Ministry of Science and Innovation (MICINN): AGL2010-22319-C03-02 and AGL2009-13906-C02-02; Fundació “La Marató de TV3”: 294/C/2015. AS-V holds a Miguel Servet I contract (CP12/03299, Instituto de Salud Carlos III, Spain). The funding sources had no involvement in the study design, data collection, analyses, and interpretation of the data or writing of the manuscript.
dc.format.mimetype application/pdf
dc.identifier.citation Bargalló N, Gilabert R, Romero-Mamani ES, Cofán M, Calder PC, Fitó M. et al. Red blood cell eicosapentaenoic acid inversely relates to MRI-assessed carotid plaque lipid core burden in elders at high cardiovascular risk. Nutrients. 2017 Sep 20;9(9). pii: E1036. DOI: 10.3390/nu9091036.
dc.identifier.doi http://dx.doi.org/10.3390/nu9091036
dc.identifier.issn 2072-6643
dc.identifier.uri http://hdl.handle.net/10230/35040
dc.language.iso eng
dc.publisher MDPIca
dc.relation.ispartof Nutrients. 2017 Sep 20;9(9):E1036
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/AGL2010-22319-C03-02
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/AGL2009-13906-C02-02
dc.rights Copyright © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Red blood cell eicosapentaenoic acid inversely relates to MRI-assessed carotid plaque lipid core burden in elders at high cardiovascular riskca
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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