Impact of remdesivir on the treatment of COVID-19 during the first wave in Spain

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• dc.contributor.author Soriano, Alejandro
• dc.contributor.author Montejano, Rocío
• dc.contributor.author Sanz-Moreno, José
• dc.contributor.author Figueira, Juan Carlos
• dc.contributor.author Grau Cerrato, Santiago
• dc.contributor.author Güerri Fernández, Roberto
• dc.contributor.author Castro-Gómez, Antonio
• dc.contributor.author Pérez-Román, Inés
• dc.contributor.author Hidalgo-Vega, Álvaro
• dc.contributor.author González-Domínguez, Almudena
• dc.date.accessioned 2021-12-17T07:25:17Z
• dc.date.available 2021-12-17T07:25:17Z
• dc.date.issued 2021
• dc.description.abstract Introduction: Spain was one of the most affected countries during the first wave of COVID-19, having the highest mortality rate in Europe. The aim of this retrospective study is to estimate the impact that remdesivir-the first drug for COVID-19 approved in the EU-would have had in the first wave. Methods: This study simulated the impact that remdesivir could have had on the Spanish National Health System (SNHS) capacity (bed occupancy) and the number of deaths that could have been prevented, based on two scenarios: a real-life scenario (without remdesivir) and an alternative scenario (with remdesivir). It considered the clinical results of the ACTT-1 trial in hospitalized patients with COVID-19 and pneumonia who required supplemental oxygen. The occupancy rates in general wards and ICUs were estimated in both scenarios.Results: Remdesivir use could have prevented the admission of 2587 patients (43.75%) in the ICUs. It could have also increased the SNHS capacity in 5656 general wards beds and 1700 ICU beds, showing an increase in the number of beds available of 17.53% (95% CI 3.98%-24.42%) and 23.98% (95% CI 21.33%-28.22%), respectively, at the peak of the occupancy rates. Furthermore, remdesivir use could have prevented 7639 deaths due to COVID-19, which implies a 27.51% reduction (95% CI 14.25%-34.07%). Conclusions: Remdesivir could have relieved the pressure on the SNHS and could have reduced the death toll, providing a better strategy for the management of COVID-19 during the first wave.
• dc.format.mimetype application/pdf
• dc.identifier.citation Soriano A, Montejano R, Sanz-Moreno J, Figueira JC, Grau S, Güerri-Fernández R, Castro-Gómez A, Pérez-Román I, Hidalgo-Vega Á, González-Domínguez A. Impact of remdesivir on the treatment of COVID-19 during the first wave in Spain. Adv Ther. 2021;38(7):4057-69. DOI: 10.1007/s12325-021-01804-9
• dc.identifier.doi http://dx.doi.org/10.1007/s12325-021-01804-9
• dc.identifier.issn 0741-238X
• dc.identifier.uri http://hdl.handle.net/10230/49243
• dc.language.iso eng
• dc.publisher Springer
• dc.relation.ispartof Adv Ther. 2021;38(7):4057-69
• dc.rights © The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
• dc.subject.keyword Bed occupancy
• dc.subject.keyword COVID-19
• dc.subject.keyword ICU
• dc.subject.keyword Remdesivir
• dc.subject.keyword Spain
• dc.title Impact of remdesivir on the treatment of COVID-19 during the first wave in Spain
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion