SARS-CoV-2 infection modulates ACE2 function and subsequent inflammatory responses in swabs and plasma of COVID-19 patients

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• dc.contributor.author Gutiérrez-Chamorro, Lucía
• dc.contributor.author Riveira Muñoz, Eva
• dc.contributor.author Barrios Barrera, Clara
• dc.contributor.author Palau González, Vanesa
• dc.contributor.author Nevot, Maria
• dc.contributor.author Pedreño-López, Sònia
• dc.contributor.author Senserrich, Jordi
• dc.contributor.author Massanella Luna, Marta, 1983-
• dc.contributor.author Clotet, Bonaventura
• dc.contributor.author Cabrera, Cecilia
• dc.contributor.author Mitjà, Oriol
• dc.contributor.author Crespo Barrio, Marta
• dc.contributor.author Pascual Santos, Julio
• dc.contributor.author Riera, Marta
• dc.contributor.author Ballana Guix, Ester
• dc.date.accessioned 2022-07-14T07:13:05Z
• dc.date.available 2022-07-14T07:13:05Z
• dc.date.issued 2021
• dc.description.abstract Angiotensin converting enzyme 2 (ACE2) is a host ectopeptidase and the receptor for the SARS-CoV-2 virus, albeit virus-ACE2 interaction goes far beyond viral entry into target cells. Controversial data exists linking viral infection to changes in ACE2 expression and function, which might influence the subsequent induction of an inflammatory response. Here, we tested the significance of soluble ACE2 enzymatic activity longitudinally in nasopharyngeal swabs and plasma samples of SARS-CoV-2 infected patients, along with the induction of inflammatory cytokines. Release of soluble functional ACE2 increases upon SARS-CoV-2 infection in swabs and plasma of infected patients, albeit rapidly decreasing during infection course in parallel with ACE2 gene expression. Similarly, SARS-CoV-2 infection also induced the expression of inflammatory cytokines. These changes positively correlated with the viral load. Overall, our results demonstrate the existence of mechanisms by which SARS-CoV-2 modulates ACE2 expression and function, intracellular viral sensing and subsequent inflammatory response, offering new insights into ACE2 dynamics in the human upper respiratory tract and pointing towards soluble ACE2 levels as a putative early biomarker of infection severity.
• dc.format.mimetype application/pdf
• dc.identifier.citation Gutiérrez-Chamorro L, Riveira-Muñoz E, Barrios C, Palau V, Nevot M, Pedreño-López S, et al. SARS-CoV-2 infection modulates ACE2 function and subsequent inflammatory responses in swabs and plasma of COVID-19 patients. Viruses. 2021 Aug 28; 13(9): 1715. DOI: 10.3390/v13091715
• dc.identifier.doi http://dx.doi.org/10.3390/v13091715
• dc.identifier.issn 1999-4915
• dc.identifier.uri http://hdl.handle.net/10230/53732
• dc.language.iso eng
• dc.publisher MDPI
• dc.rights © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword SARS-CoV-2-ACE2
• dc.subject.keyword Biomarker
• dc.subject.keyword Inflammation
• dc.title SARS-CoV-2 infection modulates ACE2 function and subsequent inflammatory responses in swabs and plasma of COVID-19 patients
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion